{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:02:32Z","timestamp":1773763352984,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4_suppl","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>While preclinical studies suggest that mitochondria play a pivotal role in ischaemia\u2013reperfusion injury, the knowledge of mitochondrial function in human out-of-hospital cardiac arrest remains scarce. The present study sought to compare oxidative phosphorylation capacity in skeletal muscle biopsies from out-of-hospital cardiac arrest patients to healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>This was a substudy of a randomised trial comparing targeted temperature management at 33\u00b0C versus 36\u00b0C for out-of-hospital cardiac arrest patients. Skeletal muscle biopsies were obtained from adult resuscitated comatose out-of-hospital cardiac arrest patients 28 hours after initiation of targeted temperature management, i.e. at target temperature prior to rewarming, and from age-matched healthy controls. Mitochondrial function was analysed by high-resolution respirometry. Maximal sustained respiration through complex I, maximal coupled respiration through complex I and complex II and maximal electron transport system capacity was compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>A total of 20 out-of-hospital cardiac arrest patients and 21 controls were included in the analysis. We found no difference in mitochondrial function between temperature allocations. We found no difference in complex I sustained respiration between out-of-hospital cardiac arrest and controls (23 (18\u201326) vs. 22 (19\u201326) pmol O2\/mg\/s, P=0.76), whereas coupled complex I and complex II respiration was significantly lower in out-of-hospital cardiac arrest patients versus controls (53 (42\u201359) vs. 64 (54\u201368) pmol O2\/mg\/s, P=0.01). Furthermore, electron transport system capacity was lower in out-of-hospital cardiac arrest versus controls (63 (51\u201369) vs. 73 (66\u201378) pmol O2\/mg\/s, P=0.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Mitochondrial oxidative phosphorylation capacity in skeletal muscle biopsies was reduced in out-of-hospital cardiac arrest patients undergoing targeted temperature management compared to age-matched, healthy controls. The role of mitochondria as risk markers and potential targets for post-resuscitation care remains unknown.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1177\/2048872618814700","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T10:44:59Z","timestamp":1552301099000},"page":"S138-S144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest"],"prefix":"10.1093","volume":"9","author":[{"given":"Sebastian","family":"Wiberg","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark"},{"name":"Department of Emergency Medicine, Beth Israel Deaconess Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nis","family":"Stride","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bro-Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias J","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beth Israel Deaconess Medical Center, USA"},{"name":"Research Center for Emergency Medicine, Aarhus University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen","family":"Larsen","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, University of Copenhagen, Denmark"},{"name":"Clinical Research Centre, Medical University of Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W","family":"Donnino","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beth Israel Deaconess Medical Center, USA"},{"name":"Department of Internal Medicine, Beth Israel Deaconess Medical Center, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Dela","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, University of Copenhagen, Denmark"},{"name":"Department of Geriatrics, Bispebjerg Hospital, 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