{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:40:05Z","timestamp":1768545605486,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Heart Journal: Acute Cardiovascular Care"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Electrocardiography (ECG) signs, typical or acute pulmonary embolism, and their changes can be used for the prediction of clinical and haemodynamic outcomes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose:<\/jats:title><jats:p> To study the predictive value of the resolution of admission ECG signs in higher risk pulmonary embolism patients for 30-day survival and for the decrease in right ventricular systolic pressure. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We analysed the 12-lead ECGs at admission and daily for the first 5 days after hospitalisation in 110 intermediate-high and high-risk pulmonary embolism patients admitted to the intensive care unit of a single tertiary centre. The predictive value of the resolution of four ECG signs were analysed for 30-day survival and for the changes in right ventricular systolic pressure during hospitalisation: S-wave in the first standard lead, right bundle branch block pattern, S-wave in the aVL lead and negative T-waves in precordial leads. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> ECG recordings showed the existence of S-wave in the I lead in 71 (64.5%), S-wave in the aVL in 77 (70%), right bundle branch block pattern in 30 (27.3%) and negative T-waves in 66 (60%) patients. All-cause 30-day in-hospital mortality was 13.6%. Among the ECG signs, only the presence of right bundle branch block at admission was significantly associated with 30-day all-cause mortality (hazard ratio (HR) adjusted for age, gender and right ventricular systolic pressure at admission was 7.7, 95% confidence interval (CI) 2.1\u201327.9; P=0.002). The resolution of three ECG signs during the first 5 days of hospitalisation, S-wave in the I lead (HR 26.4, 95% CI 3.1\u2013226.6; P=0.003), S-wave in the aVL (HR 21.5, 95% CI 2.6\u2013175.3; P=0.004) and right bundle branch block configuration (HR 5.2, 95% CI 1.3\u201320.8; P=0.020) were associated with 30-day survival. The intermediate-high and high-risk pulmonary embolism patients with S-wave resolution in lead aVL had 0.0% and 7.1% 30-day all-cause mortality, respectively. The patients with resolution of the S-wave in the first lead and in aVL as well as right bundle branch block had more pronounced changes in right ventricular systolic pressure at discharge (27\u00b113 vs. 13\u00b115 mmHg; P=0.011 for S-wave in I lead resolution, 27\u00b112 vs. 15\u00b117 mmHg; P=0.004 for S-wave in aVL resolution and 23\u00b114 vs. 9\u00b114 mmHg; P=0.040 for right bundle branch block resolution) than patients without resolution. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Resolution of S-waves and right bundle branch block in ECG correlates with lower all-cause 30-day mortality in intermediate-high and high-risk pulmonary embolism patients. Resolution of S-waves in the first lead and in aVL and right bundle branch block correlates with a decrease of right ventricular systolic pressure. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2048872618823441","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T15:23:35Z","timestamp":1547220215000},"page":"271-278","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Electrocardiography changes and their significance during treatment of patients with intermediate-high and high-risk pulmonary embolism"],"prefix":"10.1093","volume":"9","author":[{"given":"Natasha","family":"Novicic","sequence":"first","affiliation":[{"name":"Clinic of Cardiology and Urgent Internal Medicine, Military Medical Academy, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Dzudovic","sequence":"additional","affiliation":[{"name":"Clinic of Cardiology and Urgent 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