{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:07:13Z","timestamp":1788480433016,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infectious endocarditis is often complicated by conduction abnormalities at the time of presentation. Cardiac surgery is the treatment of choice for many infectious endocarditis patients, but carries an additional risk of persistent postoperative conduction abnormality. We sought to define the incidence and clinical predictors of significant postoperative conduction abnormalities necessitating permanent pacemaker implantation after cardiac surgery for infectious endocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients with infectious endocarditis who were surgically treated at Cleveland Clinic from 2007 to 2013 were identified using the Cleveland Clinic Infective Endocarditis Registry and the Cardiovascular Information Registry. Patients with a pre-existing cardiac implantable electronic device were excluded. The primary outcome was the need for permanent pacemaker placement postoperatively for atrioventricular block. Regression analysis was performed to identify risk factors for permanent pacemaker requirement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 444 infectious endocarditis patients who underwent cardiac surgery for infectious endocarditis, 57 (13%) required postoperative permanent pacemaker for atrioventricular block. Multivariable analysis identified that prolongation in preoperative PR and QRS intervals, Staphylococcus aureus as the infectious endocarditis organism, the presence of intracardiac abscess, tricuspid valve involvement, and prior valvular surgery independently predicted postoperative permanent pacemaker placement. The developed model exhibited excellent predictive ability (c-statistic 0.88) and calibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infectious endocarditis cardiac surgery patients often require a postoperative permanent pacemaker. Preoperative conduction abnormality, S. aureus infection, abscess, tricuspid valve involvement, and prior valvular surgery are strong predictors of postoperative permanent pacemaker placement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2048872619848661","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:42:05Z","timestamp":1562240525000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictors of permanent pacemaker requirement after cardiac surgery for infective endocarditis"],"prefix":"10.1093","volume":"10","author":[{"given":"Terence E","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich L","family":"Kiehl","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabin K","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gosta B","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Departmens of Cardiothoracic Surgery, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitra","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Hussain","sequence":"additional","affiliation":[{"name":"Departmens of Cardiothoracic Surgery, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama","family":"Wazni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L","family":"Wilkoff","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaldoun G","family":"Tarakji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"2021072117321483000_zuaa052-B1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.jacc.2015.03.518","article-title":"Trends in infective endocarditis incidence, microbiology, and valve replacement in the United States from 2000 to 2011","volume":"65","author":"Pant","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2021072117321483000_zuaa052-B2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.14740\/jocmr3131w","article-title":"Epidemiology of infective endocarditis in rural upstate New York, 2011\u20132016","volume":"9","author":"Fatima","year":"2017","journal-title":"J Clin Med Res"},{"key":"2021072117321483000_zuaa052-B3","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.jtcvs.2016.09.093","article-title":"The American Association for Thoracic Surgery (AATS) consensus guidelines: surgical treatment of infective endocarditis: executive summary","volume":"153","author":"Pettersson","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021072117321483000_zuaa052-B4","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIR.0000000000000296","article-title":"Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications","volume":"132","author":"Baddour","year":"2015","journal-title":"Circulation"},{"key":"2021072117321483000_zuaa052-B5","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"ESC Guidelines for the management of infective endocarditis: the Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). 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