{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:15Z","timestamp":1787019375447,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4_suppl","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Activation of the complement system is known to be a potent inducer of systemic inflammation, which is an important component of post-cardiac arrest syndrome. Mannan-binding-lectin associated protein of 19 kDa (MAp19) is suggested to be a regulatory component of the lectin pathway of complement activation. The aims of this study were to describe serial levels of MAp19 protein in comatose survivors of out-of-hospital cardiac arrest (OHCA), to evaluate the effect of two different regimes of targeted temperature management and to investigate the possible association between levels of MAp19 and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this post-hoc study, we analysed data from two large randomized controlled studies: \u2018Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest\u2019 (TTM) and \u2018Targeted temperature management for 48 versus 24 h and neurological outcome after out-of-hospital cardiac arrest\u2019 (TTH). We measured serial levels of MAp19 in 240 patients within 72 h after OHCA and in 82 healthy controls. The effect of targeted temperature management on MAp19 levels was analysed according to temperature allocation in main trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>MAp19 levels were significantly lower in OHCA patients within 48 h after OHCA (p-values &amp;lt;0.001) compared with healthy controls. A target temperature at 33\u00b0C compared with 36\u00b0C for 24 h was associated with significantly lower levels of MAp19 (\u201357 ng\/mL (95% confidence interval (CI): \u201397 to \u221216 mg\/mL), p=0.006). Target temperature at 33\u00b0C for 48 h compared with 24 h was not associated with a difference in MAp19 levels (\u201331 ng\/mL (95% CI: \u2013120 to 60 mg\/mL), p=0.57). Low MAp19 levels at admission were associated with higher 30-day mortality (12% vs. 38%, plog-rank =0.0008), also in adjusted analysis (two-fold higher, hazard ratio =0.48 (95% CI: 0.31 to 0.75), p=0.001). Analysis of MAp19 levels at 24\u201372 h showed they were not associated with 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Survivors after OHCA have lower levels of MAp19 protein compared with healthy controls. A targeted temperature management at 33\u00b0C compared with 36\u00b0C was associated with significantly lower MAp19 levels, whereas target temperature at 33\u00b0C for 48 h compared with 24 h did not influence MAp19 protein levels. Low MAp19 levels at admission were independently associated with increased mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2048872619870031","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T10:54:17Z","timestamp":1568976857000},"page":"S145-S152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The complement lectin pathway protein MAp19 and out-of-hospital cardiac arrest: Insights from two randomized clinical trials"],"prefix":"10.1093","volume":"9","author":[{"given":"John","family":"Bro-Jeppesen","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni N\u00f8rgaard","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Haugaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Troldborg","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Kjaergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Aarhus University Hospital, Denmark"},{"name":"Research Centre for Emergency Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wanscher","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia 4142, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"2021020117064707900_bibr1-2048872619870031","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.resuscitation.2008.09.017","article-title":"Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. 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