{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:10:50Z","timestamp":1754194250880},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pericardial effusion is frequent in the acute phase of ST-segment elevation myocardial infarction. However, its prognostic role in the era of primary percutaneous coronary intervention is not completely understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated the association between pericardial effusion, assessed by transthoracic echocardiography, and survival in a large cohort of ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention, enrolled in the Trieste primary percutaneous coronary intervention registry from January 2007 to March 2017. Multivariable analysis and a propensity score approach were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1732 ST-segment elevation myocardial infarction patients were included. Median follow-up was 45 (interquartile range 19\u201379) months. Pericardial effusion was present in 246 patients (14.2%). Thirty-day all-cause mortality was similar between patients with and without pericardial effusion (7.8% vs. 5.4%, P=0.15), whereas crude long-term survival was worse in patients with pericardial effusion (26.2% vs. 17.7%, P\u22640.01). However, at multivariable analyses the presence of pericardial effusion was not associated with long-term mortality (hazard ratio 1.26, 95% confidence interval 0.86\u20131.82, P=0.22). Matching based on propensity scores confirmed the lack of association between pericardial effusion and both 30-day (hazard ratio 1, 95% confidence interval 0.42\u20132.36, P=1) and long-term (hazard ratio 1.14, 95% confidence interval 0.74\u20131.78, P=0.53) all-cause mortality. Patients with per effusion experienced a higher incidence of free wall rupture (2.8% vs. 0.5%, P&amp;lt;0.0001) independently of the entity of pericardial effusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, the onset of pericardial effusion after ST-segment elevation myocardial infarction is not independently associated with short and long-term higher mortality. Free wall rupture has to be considered rare compared to the fibrinolytic era and occurs more frequently in patients with pericardial effusion, suggesting a close monitoring of these patients in the early post-primary percutaneous coronary intervention phase.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1177\/2048872619884858","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T10:45:51Z","timestamp":1573123551000},"page":"71-80","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic relevance of pericardial effusion in STEMI patients treated by primary percutaneous coronary intervention: a 10-year single-centre experience"],"prefix":"10.1093","volume":"10","author":[{"given":"Stefano","family":"Albani","sequence":"first","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Fabris","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Stolfo","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Falco","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Barbati","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Donato","family":"Aquaro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fondazione Toscana G Monasterio, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Vitrella","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Rakar","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Korcova","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardina","family":"Lardieri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Azienda per l\u2019Assistenza Sanitaria n 2 Bassa Friulana-Isontina, Gorizia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Interventional Cardiology Unit, GVM Care and Research Maria Cecilia Hospital, Ravenna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Perkan","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"2021072111395751800_zuaa057-bibr1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.amjcard.2013.11.071","article-title":"Predictors of moderate-to-severe pericardial effusion, cardiac tamponade, and electromechanical dissociation in patients with ST-elevation myocardial infarction","volume":"113","author":"Figueras","year":"2014","journal-title":"Am J Cardiol"},{"key":"2021072111395751800_zuaa057-bibr2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.CIR.81.2.477","article-title":"Factors associated with pericardial effusion in acute Q wave myocardial infarction","volume":"81","author":"Sugiura","year":"1990","journal-title":"Circulation"},{"key":"2021072111395751800_zuaa057-bibr3","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.amjcard.2015.07.007","article-title":"Effect of 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