{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:10Z","timestamp":1787019370538,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0032968"],"award-info":[{"award-number":["NNF18OC0032968"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004102","name":"Laerdal Foundation","doi-asserted-by":"publisher","award":["3374"],"award-info":[{"award-number":["3374"]}],"id":[{"id":"10.13039\/501100004102","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eva og Henry Fr\u00e6nkels Mindefond; Direkt\u00f8r Emil C Hertz og hustru Inger Hertz Fond"},{"DOI":"10.13039\/501100010371","name":"Raimond og Dagmar Ringg\u00e5rd-Bohns Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inhaled nitric oxide (iNO) effectively reduces right ventricular afterload when administered in the immediate phase of acute pulmonary embolism (PE) in preclinical animal models. In a porcine model of intermediate-risk PE, we aimed to investigate whether iNO has pulmonary vasodilator efficacy both in the immediate and prolonged phase of acute PE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anesthetized pigs (n\u2009=\u200918) were randomized into three subgroups. An acute PE iNO-group (n\u2009=\u20096) received iNO at 40 ppm at one, three, six, nine and 12 hours after onset of PE. Vehicle animals (n\u2009=\u20096) received PE, but no active treatment. A third group of sham animals (n\u2009=\u20096) received neither PE nor treatment. Animals were evaluated using intravascular pressures, respiratory parameters, biochemistry and intracardiac pressure-volume measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The administration of PE increased mean pulmonary artery pressure (mPAP) (vehicle vs sham; 33.3 vs 17.7\u2009mmHg, p\u2009&amp;lt;\u20090.0001), pulmonary vascular resistance (vehicle vs sham; 847.5 vs 82.0 dynes, p\u2009&amp;lt;\u20090.0001) and right ventricular arterial elastance (vehicle vs sham; 1.2 vs 0.2\u2009mmHg\/ml, p\u2009&amp;lt;\u20090.0001). Significant mPAP reduction by iNO was preserved at 12 hours after the onset of acute PE (vehicle vs iNO; 0.5 vs \u20133.5\u2009mmHg, p\u2009&amp;lt;\u20090.0001). However, this response was attenuated over time (p\u2009=\u20090.0313). iNO did not affect the systemic circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iNO is a safe and effective pulmonary vasodilator both in the immediate and prolonged phase of acute PE in an in-vivo porcine model of intermediate-risk PE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2048872620918713","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T06:05:05Z","timestamp":1594706705000},"page":"265-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhaled nitric oxide has pulmonary vasodilator efficacy both in the immediate and prolonged phase of acute pulmonary 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads Dam","family":"Lyhne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Erik","family":"Nielsen-Kudsk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, 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