{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:58:30Z","timestamp":1778770710637,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>With increases in life expectancy, percutaneous coronary intervention is being performed more often, even in elderly patients with acute myocardial infarction. However, the optimal management of nonagenarians with acute myocardial infarction is uncertain. This study sought to investigate clinical outcomes of nonagenarians who undergo percutaneous coronary intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Of 2640 consecutive patients with acute myocardial infarction hospitalised within 24 hours after symptom onset in 2009\u20132018, we prospectively analysed 96 nonagenarians (median age 92\u202fyears; interquartile range 91\u201394) who underwent percutaneous coronary intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median follow-up period was 375 days. Inhospital major bleeding (Bleeding Academic Research Consortium type 3 or 5) and inhospital death occurred in 15.6% and 17.7% of patients, respectively. The proportion of patients with frailty increased during hospitalisation, from 43.8% (mild frailty 37.5%; moderate to severe frailty 6.3%) at admission to 60.7% (mild frailty 46.8%; moderate to severe frailty 13.9%) at discharge (P\u2009&amp;lt;\u20090.01). The cumulative incidence of all-cause mortality was 22.2% at 180 days and 27.5% at 365 days. After adjusting for confounders, cardiogenic shock (hazard ratio (HR) 2.85; 95% confidence interval (CI) 1.07\u20137.64) and final thrombolysis in myocardial infarction flow grade less than 3 (HR 2.45; 95% CI 1.03\u20135.58) were associated with higher mid-term mortality and cardiac rehabilitation (HR 0.25; 95% CI, 0.13\u20130.50) was associated with lower mid-term mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The mid-term mortality of selected nonagenarians with acute myocardial infarction who undergo percutaneous coronary intervention is reasonable, but older patients have high rates of inhospital major bleeding and progression of frailty. This study provides physicians, patients and families with important information for therapeutic decision-making.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1177\/2048872620921596","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T14:58:20Z","timestamp":1587653900000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical outcomes of nonagenarians with acute myocardial infarction who undergo percutaneous coronary intervention"],"prefix":"10.1093","volume":"9","author":[{"given":"Kensaku","family":"Nishihira","sequence":"first","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital, Japan"},{"name":"Department of Cardiovascular Medicine, University of Miyazaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehiro","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshisato","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"2021020117084840700_bibr1-2048872620921596","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics \u2013 2018 update: a report from the American Heart Association.","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"2021020117084840700_bibr2-2048872620921596","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.jacc.2017.12.068","article-title":"Coronary artery disease in patients \u226580 years of age","volume":"71","author":"Madhavan","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2021020117084840700_bibr3-2048872620921596","first-page":"1","article-title":"Impact of emergency coronary intervention in a super-aging population","volume":"20","author":"Kojima","year":"2018","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2021020117084840700_bibr4-2048872620921596","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijcard.2006.12.027","article-title":"Causes of ineligibility in randomized controlled trials and long-term mortality in patients with non-ST-segment elevation acute coronary syndromes","volume":"124","author":"Bosch","year":"2008","journal-title":"Int J Cardiol"},{"key":"2021020117084840700_bibr5-2048872620921596","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/eurheartj\/ehu197","article-title":"Importance of frailty in patients with cardiovascular disease","volume":"35","author":"Singh","year":"2014","journal-title":"Eur Heart J"},{"key":"2021020117084840700_bibr6-2048872620921596","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/eurheartj\/ehs184","article-title":"Third universal definition of myocardial infarction","volume":"33","author":"Thygesen","year":"2012","journal-title":"Eur Heart J"},{"key":"2021020117084840700_bibr7-2048872620921596","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"2021020117084840700_bibr8-2048872620921596","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/j.jcin.2018.08.028","article-title":"The association of frailty with in-hospital bleeding among older adults with acute myocardial infarction: Insights from the ACTION Registry","volume":"11","author":"Dodson","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"2021020117084840700_bibr9-2048872620921596","doi-asserted-by":"crossref","DOI":"10.1093\/ehjqcco\/qcaa018","article-title":". 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