{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:45:44Z","timestamp":1784051144675,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Heart Journal: Acute Cardiovascular Care"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0\u201372 hours). In a linear mixed model, PTX3 predicted IL-6 ( p\u2009&lt;\u20090.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI ( \u03c1\u2009=\u20090.23, p\u2009=\u20090.006). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2048872620923641","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T08:19:48Z","timestamp":1589444388000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage"],"prefix":"10.1093","volume":"9","author":[{"given":"Noreen","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Clinical Science, University of Bergen, Norway"},{"name":"Department of Cardiology, Stavanger University Hospital, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LK","family":"Bache-Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Research, Section of 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