{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:23:31Z","timestamp":1758637411111},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["TH-1406-6-1"],"award-info":[{"award-number":["TH-1406-6-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005970","name":"German Heart Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010578","name":"German Cardiac Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Arbeitsgemeinschaft Leitende Kardiologische Krankenhaus\u00e4rzte"},{"name":"University of Leipzig Heart Centre"},{"name":"Maquet Cardiopulmonary as well as Teleflex Medical"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conflicting results exist on whether initiation of intraaortic balloon pumping (IABP) before percutaneous coronary intervention (PCI) has an impact on outcome in this setting. Our aim was to assess the outcome of patients undergoing IABP insertion before versus after primary PCI in acute myocardial infarction complicated by cardiogenic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The IABP-SHOCK II-trial randomized 600 patients with acute myocardial infarction and cardiogenic shock to IABP-support versus control. We analysed the outcome of patients randomized to the intervention group regarding timing of IABP implantation before or after PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 600 patients included in the IABP-SHOCK II trial, 301 were randomized to IABP-support. We analysed the 275 (91%) patients of this group undergoing primary PCI as revascularization strategy surviving the initial procedure. IABP insertion was performed before PCI in 33 (12%) and after PCI in 242 (88%) patients. There were no differences in baseline arterial lactate (p\u2009=\u20090.70), Simplified Acute Physiology Score-II-score (p\u2009=\u20090.60) and other relevant baseline characteristics. No differences were observed for short- and long-term mortality (pre vs. post 30-day mortality: 36% vs. 37%, odds ratio 0.99, 95% confidence interval (CI) 0.47\u20132.12, p\u2009=\u20090.99; one-year mortality: 56% vs. 48%, hazard ratio 1.08, 95% CI 0.65\u20131.80, p\u2009=\u20090.76; six-year-mortality: 64% vs. 65%, hazard ratio 1.00, 95% CI 0.63\u20131.60, p\u2009=\u20090.99). In multivariable Cox regression analysis timing of IABP-implantation was no predictor for long-term outcome (hazard ratio 1.08, 95% CI 0.66\u20131.78, p\u2009=\u20090.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Timing of IABP-implantation pre or post primary PCI had no impact on outcome in patients with acute myocardial infarction complicated by cardiogenic shock.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2048872620930509","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T08:29:31Z","timestamp":1591777771000},"page":"54-61","update-policy":"http:\/\/dx.doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of timing of intraaortic balloon counterpulsation on mortality in cardiogenic shock \u2013 a subanalysis of the IABP-SHOCK II trial"],"prefix":"10.1093","volume":"10","author":[{"given":"Georg","family":"Fuernau","sequence":"first","affiliation":[{"name":"Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Heart Centre L\u00fcbeck, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Ledwoch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Critical Care, M\u00fcnchen Klinik Neuperlach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Germany"},{"name":"Department of Internal Medicine\/Cardiology, Heart Centre Leipzig at University of Leipzig and Leipzig Heart Institute, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Heart Centre L\u00fcbeck, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Thelemann","sequence":"additional","affiliation":[{"name":"Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Heart Centre L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital D\u00fcsseldorf, Heinrich-Heine-University D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"de Waha-Thiele","sequence":"additional","affiliation":[{"name":"Medical Clinic II (Cardiology, Angiology, Intensive Care Medicine), University Heart Centre L\u00fcbeck, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"P\u00f6ss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Centre Leipzig at University of Leipzig and Leipzig Heart Institute, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Josef","family":"Feistritzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Centre Leipzig at University of Leipzig and Leipzig Heart Institute, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Centre Leipzig at University of Leipzig and Leipzig Heart Institute, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Werdan","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine III, University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Zeymer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung, Germany"},{"name":"Medical Clinic B, Klinikum Ludwigshafen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Centre Leipzig at University of Leipzig and Leipzig Heart Institute, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"2021072111394904300_zuaa079-bibr1","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(13)61783-3","article-title":"Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): Final 12 month results of a randomised, open-label trial","volume":"382","author":"Thiele","year":"2013","journal-title":"Lancet"},{"key":"2021072111394904300_zuaa079-bibr2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1208410","article-title":"Intraaortic balloon support for myocardial infarction with cardiogenic shock","volume":"367","author":"Thiele","year":"2012","journal-title":"N Engl J Med"},{"key":"2021072111394904300_zuaa079-bibr3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ahj.2012.03.012","article-title":"Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock: Design and rationale of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial","volume":"163","author":"Thiele","year":"2012","journal-title":"Am Heart J"},{"key":"2021072111394904300_zuaa079-bibr4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1161\/CIRCULATIONAHA.118.038201","article-title":"Intraaortic balloon pump in cardiogenic shock complicating acute myocardial infarction","volume":"139","author":"Thiele","year":"2019","journal-title":"Circulation"},{"key":"2021072111394904300_zuaa079-bibr5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/clc.22184","article-title":"Have we given up on intra-aortic balloon counterpulsation in post-myocardial infarction cardiogenic shock?","volume":"36","author":"Acharji","year":"2013","journal-title":"Clin Cardiol"},{"key":"2021072111394904300_zuaa079-bibr6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.amjcard.2009.11.021","article-title":"Comparison of hospital mortality with intra-aortic balloon counterpulsation insertion before versus after primary percutaneous coronary intervention for cardiogenic shock complicating acute myocardial infarction","volume":"105","author":"Abdel-Wahab","year":"2010","journal-title":"Am J Cardiol"},{"key":"2021072111394904300_zuaa079-bibr7","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4103\/0366-6999.183428","article-title":"Efficacy of intra-aortic balloon pump before versus after primary percutaneous coronary intervention in patients with cardiogenic shock from ST-elevation myocardial infarction","volume":"129","author":"Yuan","year":"2016","journal-title":"Chin Med J (Engl)"},{"key":"2021072111394904300_zuaa079-bibr8","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJM199309023291001","article-title":"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction","volume":"329","year":"1993","journal-title":"N Engl J Med"},{"key":"2021072111394904300_zuaa079-bibr9","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1016\/j.ijcard.2013.06.009","article-title":"Impact of intra-aortic balloon pump support initiated before versus after primary percutaneous coronary intervention in patients with cardiogenic shock from acute myocardial infarction","volume":"168","author":"Cheng","year":"2013","journal-title":"Int J Cardiol"},{"key":"2021072111394904300_zuaa079-bibr10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12471-012-0312-8","article-title":"Efficacy and timing of intra-aortic counterpulsation in patients with ST-elevation myocardial infarction complicated by cardiogenic shock","volume":"20","author":"Sjauw","year":"2012","journal-title":"Neth Heart J"},{"key":"2021072111394904300_zuaa079-bibr11","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1001\/jama.2010.1190","article-title":"Elective intra-aortic balloon counterpulsation during high-risk percutaneous coronary intervention: A randomized controlled trial","volume":"304","author":"Perera","year":"2010","journal-title":"JAMA"},{"key":"2021072111394904300_zuaa079-bibr12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ahj.2011.03.037","article-title":"A multicenter, randomized, controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size prepercutaneous coronary intervention for acute myocardial infarction: rationale and design of the Counterpulsation Reduces Infarct Size Acute Myocardial Infarction trial","volume":"162","author":"Patel","year":"2011","journal-title":"Am Heart J"},{"key":"2021072111394904300_zuaa079-bibr13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/SHK.0b013e31824a67af","article-title":"Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: The prospective, randomized IABP shock trial","volume":"37","author":"Prondzinsky","year":"2012","journal-title":"Shock"},{"key":"2021072111394904300_zuaa079-bibr14","author":"Dhruva"},{"key":"2021072111394904300_zuaa079-bibr15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/joic.12080","article-title":"The current use of Impella 2.5 in acute myocardial infarction complicated by cardiogenic shock: Results from the USpella Registry","volume":"27","author":"O\u2019Neill","year":"2014","journal-title":"J Interv Cardiol"},{"key":"2021072111394904300_zuaa079-bibr16","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/ccd.28307","article-title":"Improved outcomes associated with the use of shock protocols: Updates from the National Cardiogenic Shock Initiative","volume":"93","author":"Basir","year":"2019","journal-title":"Catheter Cardiovasc Interv"},{"key":"2021072111394904300_zuaa079-bibr17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCULATIONAHA.118.038269","article-title":"Unloading the left ventricle before reperfusion in patients with anterior ST-segment-elevation myocardial infarction","volume":"139","author":"Kapur","year":"2019","journal-title":"Circulation"}],"container-title":["European Heart Journal. Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2048872620930509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2048872620930509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ehjacc\/article-pdf\/10\/1\/54\/39201108\/zuaa079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjacc\/article-pdf\/10\/1\/54\/39201108\/zuaa079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:24:12Z","timestamp":1696227852000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/10\/1\/54\/6145538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,6,10]]},"published-print":{"date-parts":[[2021,3,5]]}},"URL":"https:\/\/doi.org\/10.1177\/2048872620930509","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,6,10]]}}}