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Venomous animals are frequently stereotyped as inflictors of pain and distress and have historically been vilified by mankind. Yet, ironically, the very venoms that cause pain when directly injected by the host animal may actually turn out to contain the next generation of analgesics when injected by the clinician. The last 12 months have seen dramatic discoveries of analgesic tools within venoms. Spiders, snakes and even centipedes are yielding peptides with immense therapeutic potential. Significant advances are also taking place in delivery methods that can improve bioavailability and pharmacokinetics of these exciting natural resources. Turning proteinaceous venom into pharmaceutical liquid gold is the goal of venomics and the focus of this article.<\/jats:p>","DOI":"10.1177\/2049463713502005","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T22:11:00Z","timestamp":1378246260000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Venom: the sharp end of pain therapeutics"],"prefix":"10.1177","volume":"7","author":[{"given":"Steven A","family":"Trim","sequence":"first","affiliation":[{"name":"Venomtech Ltd, Kent Enterprise Hub, University of Kent, Canterbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol M","family":"Trim","sequence":"additional","affiliation":[{"name":"Venomtech Ltd, Kent Enterprise Hub, University of Kent, Canterbury, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"bibr1-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-9-282"},{"key":"bibr2-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01131.x"},{"key":"bibr3-2049463713502005","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S33408"},{"key":"bibr4-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.066332"},{"key":"bibr5-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.012153"},{"key":"bibr6-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3404"},{"key":"bibr7-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1038\/nature05413"},{"key":"bibr8-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216080109"},{"key":"bibr9-2049463713502005","doi-asserted-by":"publisher","DOI":"10.3390\/toxins4080620"},{"key":"bibr10-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2007.01.008"},{"key":"bibr11-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3721-12.2013"},{"key":"bibr12-2049463713502005","first-page":"CD007393","volume":"2","author":"Derry S","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr13-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.04.008"},{"key":"bibr14-2049463713502005","doi-asserted-by":"publisher","DOI":"10.1038\/nature11494"},{"key":"bibr15-2049463713502005","doi-asserted-by":"publisher","DOI":"10.4161\/chan.24161"},{"key":"bibr16-2049463713502005","unstructured":"PubMed. 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