{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:52:39Z","timestamp":1783993959354,"version":"3.55.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Pain"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Pain is considered to be one of a number of idiosyncratic, context-dependent \u2018protective actions\u2019 projected into the conscious domain by the central nervous system (CNS), as a result of a series of complex interactions in response to perceived threat. A model is described which proposes chronic pain and a variety of long-term, systemic functional neurological conditions to be a consequence of significant dysregulation of these protection systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>The Model:<\/jats:title>\n                    <jats:p>Previous research has demonstrated that a cognitive\u2013behavioural model, first described in 1995 by Surawy et al., for chronic fatigue has been successful in predicting the transition from acute to chronic states in a number of conditions. This model includes predisposing, precipitating and perpetuating biopsychosocial factors. This article discusses the potential role of these factors in affecting descending inhibition in the CNS, significantly altering its ability to modulate the threat detection system. The development of \u2018central sensitisation\u2019 is considered in this context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This model proposes that chronic pain, chronic fatigue and other so-called functional neurological phenomena can, perhaps, be more helpfully seen as the actions of a dysregulated neurological protection system, rather than symptoms of an untreatable and deteriorating medical condition. Recommendations are made for the development of appropriate therapeutic interventions indicated by this model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2049463718799784","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T06:32:30Z","timestamp":1536561150000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic pain: a consequence of dysregulated protective action"],"prefix":"10.1177","volume":"13","author":[{"given":"Patrick","family":"Hill","sequence":"first","affiliation":[{"name":"Royal United Hospital, Bath, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"bibr1-2049463718799784","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.1030"},{"issue":"6","key":"bibr2-2049463718799784","first-page":"422","volume":"24","author":"Eccleston 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