{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:54:32Z","timestamp":1777463672326,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Pain"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Paracetamol is commonly used for its antipyretic properties and analgesic effects, but the central mechanism remains elusive. We designed a study in healthy volunteers to detect the central functional working mechanism of paracetamol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects, material and methods:<\/jats:title>\n                    <jats:p>A total of 20 subjects had a baseline functional magnetic resonance imaging (fMRI) before the intake of 1000 mg paracetamol orally; 60 minutes later, a second fMRI was made aiming detection of regional blood flow differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A decreased connectivity was observed in the ventral volume of interest (VOI), with the posterior cingulate (with both the left anterior cingulate cortex (ACC) and right ACC: respectively, Ke = 576; t = \u22126.8894 and Ke = 185; t = \u22124.8178) and the inferior temporal left (Ke = 103; t = \u22125.0993); in the combined ventral and dorsal VOIs, the posterior cingulate (with the left ACC; Ke = 149; t = \u22124.5658) and, both with the right ACC, the inferior temporal left (Ke = 88; t = \u22123.8456) and the inferior frontal gyrus (Ke = 86; t = \u22124.3937) had a decrease in connectivity. An increase was seen in other regions, including, among others, the middle frontal and temporal gyri (respectively, Ke = 85; t = 4.4256 and Ke = 85; t = 5.6851), the inferior frontal (with the left ACC: Ke = 165; t = 4.4998) and the superior frontal gyrus (with the right ACC; Ke = 281; t = 4.5992), and the post\/precentral gyrus (with the right ACC, respectively, Ke = 102; t = 6.0582 and Ke = 105; t = 4.0776).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>On fMRIs in healthy volunteers, the ingestion of paracetamol affects connections with the ACC. This suggests a central effect of paracetamol in cerebral areas known to be associated with pain. Further studies are needed to demonstrate the same effects in acute and chronic pain states.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2049463719854483","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T04:42:55Z","timestamp":1559623375000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of the cerebral effects of paracetamol in healthy subjects: an fMRI study"],"prefix":"10.1177","volume":"14","author":[{"given":"Olivier","family":"De Coster","sequence":"first","affiliation":[{"name":"Pain Clinic, Algemeen Ziekenhuis Delta (AZ Delta), Roeselare, Belgium"},{"name":"Pain Clinic, Department of Anesthesiology and Perioperative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-8439","authenticated-orcid":false,"given":"Patrice","family":"Forget","sequence":"additional","affiliation":[{"name":"Pain Clinic, Department of Anesthesiology and Perioperative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"De Mey","sequence":"additional","affiliation":[{"name":"Department of Radiology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Van Schuerbeek","sequence":"additional","affiliation":[{"name":"Department of Radiology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Poelaert","sequence":"additional","affiliation":[{"name":"Pain Clinic, Department of Anesthesiology and Perioperative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"bibr1-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(78)90265-0"},{"key":"bibr2-2049463719854483","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198600324-00005"},{"key":"bibr3-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90524-6"},{"key":"bibr4-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.40"},{"key":"bibr5-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1995.tb00258.x"},{"key":"bibr6-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1007\/s002100100484"},{"key":"bibr7-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.085431"},{"key":"bibr8-2049463719854483","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.02.020"},{"issue":"1","key":"bibr9-2049463719854483","first-page":"8","volume":"278","author":"Pelissier 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