{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:28:24Z","timestamp":1785176904043,"version":"3.55.0"},"reference-count":175,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Enterobacteriaceae showing resistance to cephalosporins due to extended-spectrum \u03b2-lactamases (ESBLs) or plasmid-mediated AmpC enzymes, and those producing carbapenemases have spread worldwide during the last decades. Many of these isolates are also resistant to other first-line agents such as fluoroquinolones or aminoglycosides, leaving few available options for therapy. Thus, older drugs such as colistin and fosfomycin are being increasingly used. Infections caused by these bacteria are associated with increased morbidity and mortality compared with those caused by their susceptible counterparts. Most of the evidence supporting the present recommendations is from in\u00a0vitro data, animal studies, and observational studies. While carbapenems are considered the drugs of choice for ESBL and AmpC producers, recent data suggest that certain alternatives may be suitable for some types of infections. Combined therapy seems superior to monotherapy in the treatment of invasive infections caused by carbapenemase-producing Enterobacteriaceae. Optimization of dosage according to pharmacokinetics\/pharmacodynamics data is important for the treatment of infections caused by isolates with borderline minimum inhibitory concentration due to low-level resistance mechanisms. The increasing frequency and the rapid spread of multidrug resistance among the Enterobacteriaceae is a true and complex public health problem.<\/jats:p>","DOI":"10.1177\/2049936113476284","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T22:36:23Z","timestamp":1362782183000},"page":"49-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Clinical management of infections caused by multidrug-resistant\n                    <i>Enterobacteriaceae<\/i>"],"prefix":"10.1177","volume":"1","author":[{"given":"Mercedes","family":"Delgado-Valverde","sequence":"first","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Unit, Hospital Universitario Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Sojo-Dorado","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Unit, Hospital Universitario Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Pascual","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Unit, Hospital Universitario Virgen Macarena, and Department of Microbiology, University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Rodr\u00edguez-Ba\u00f1o","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Clinical Microbiology Unit, Hospital Universitario Virgen Macarena, Avda Dr Fedriani 3, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"bibr1-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00572-10"},{"key":"bibr2-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05682-11"},{"key":"bibr3-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1980.0049"},{"key":"bibr4-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00015-07"},{"key":"bibr5-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr317"},{"key":"bibr6-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.1040-1042.2004"},{"key":"bibr7-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm180"},{"key":"bibr8-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01176-07"},{"key":"bibr9-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.06.015"},{"key":"bibr10-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1021\/bi049135y"},{"key":"bibr11-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00026-10"},{"key":"bibr12-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01420-10"},{"key":"bibr13-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.06.003"},{"key":"bibr14-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01009-09"},{"key":"bibr15-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"bibr16-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03821.x"},{"key":"bibr17-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.08.011"},{"key":"bibr18-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.01957.x"},{"key":"bibr19-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01312-09"},{"key":"bibr20-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00817-12"},{"key":"bibr21-2049936113476284","doi-asserted-by":"crossref","unstructured":"Cheong, H., Ko, K., Kang, C., Chung, D., Peck, K. and Song, J. (2012) Clinical significance of infections caused by plasmid-mediated AmpC beta-lactamases and extended-spectrum beta-lactamase-producing Escherichia coli.\n                      Infection\n                      12 September (Epub ahead of print). DOI 10.1007\/s15010\u2013012\u20130341-7.","DOI":"10.1007\/s15010-012-0341-7"},{"key":"bibr22-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/667738"},{"key":"bibr23-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01009-12"},{"key":"bibr24-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01083-07"},{"key":"bibr25-2049936113476284","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-8-585"},{"key":"bibr26-2049936113476284","unstructured":"CLSI (2010)\n                      Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement\n                      (June 2010 update). Wayne, PA: Clinical and Laboratory Standards Institute."},{"key":"bibr27-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05913-11"},{"key":"bibr28-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.01.023"},{"key":"bibr29-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03553.x"},{"key":"bibr30-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis286"},{"key":"bibr31-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.8.988.32878"},{"key":"bibr32-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.368-370.2006"},{"key":"bibr33-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0532-4"},{"key":"bibr34-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/518605"},{"key":"bibr35-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.638-645.2002"},{"key":"bibr36-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/503264"},{"key":"bibr37-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00556-09"},{"key":"bibr38-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01198-10"},{"key":"bibr39-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/380645"},{"key":"bibr40-2049936113476284","unstructured":"EUCAST (2012) Breakpoint tables for interpretation of MICs and zone diameters. Version 2.0. European Committee on Antimicrobial Susceptibility Testing. Available at: http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/Breakpoint_table_v_2.0_120221.pdf (accessed 10 January 2012)."},{"key":"bibr41-2049936113476284","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.11.49"},{"key":"bibr42-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/429323"},{"key":"bibr43-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70325-1"},{"key":"bibr44-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq237"},{"key":"bibr45-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir934"},{"key":"bibr46-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm536"},{"key":"bibr47-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01477-07"},{"key":"bibr48-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1179\/1973947812Y.0000000015"},{"key":"bibr49-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2565-2571.2003"},{"key":"bibr50-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/648451"},{"key":"bibr51-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.10.005"},{"key":"bibr52-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01290.x"},{"key":"bibr53-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01136-12"},{"key":"bibr54-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.06.004"},{"key":"bibr55-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1179\/1120009X12Z.0000000003"},{"key":"bibr56-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05927-11"},{"key":"bibr57-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq108"},{"key":"bibr58-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.06.009"},{"key":"bibr59-2049936113476284","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.diagmicrobio.2012.05.024","volume":"74","author":"Hoban D.","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"bibr60-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/314056"},{"key":"bibr61-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl414"},{"key":"bibr62-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900779"},{"key":"bibr63-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(12)00244-0"},{"key":"bibr64-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/598244"},{"key":"bibr65-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/428052"},{"key":"bibr66-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00036-08"},{"key":"bibr67-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.01.017"},{"key":"bibr68-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.760-766.2005"},{"key":"bibr69-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh462"},{"key":"bibr70-2049936113476284","author":"Kang C.","year":"2012","journal-title":"J Infect"},{"key":"bibr71-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn311"},{"key":"bibr72-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1021\/bi060723g"},{"key":"bibr73-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1021\/bi700111z"},{"key":"bibr74-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/655131"},{"key":"bibr75-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1481-1491.2002"},{"key":"bibr76-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/657242"},{"key":"bibr77-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-08"},{"key":"bibr78-2049936113476284","doi-asserted-by":"publisher","DOI":"10.3201\/eid1302.060747"},{"key":"bibr79-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr240"},{"key":"bibr80-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.09.034"},{"key":"bibr81-2049936113476284","author":"Leclercq R.","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"bibr82-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl381"},{"key":"bibr83-2049936113476284","doi-asserted-by":"crossref","unstructured":"Lee, N., Lee, C., Huang, W., Tsui, K., Hsueh, P. and Ko, W. (2012) Cefepime therapy for monomicrobial bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase-producing\n                      Enterobacteriaceae\n                      : MIC matters.\n                      Clin Infect Dis\n                      29 November (Epub ahead of print). DOI: 10.1093\/cid\/cis916.","DOI":"10.1093\/cid\/cis916"},{"key":"bibr84-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.09.004"},{"issue":"2","key":"bibr85-2049936113476284","first-page":"ii41","volume":"62","author":"Livermore D.","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"bibr86-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl043"},{"key":"bibr87-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00756-10"},{"key":"bibr88-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq408"},{"issue":"4","key":"bibr89-2049936113476284","first-page":"S437","volume":"17","author":"Lucasti C.","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"bibr90-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01859.x"},{"key":"bibr91-2049936113476284","author":"Macone A.","year":"2003","journal-title":"Abstracts Book of the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Il, USA. American Society for Microbiology"},{"key":"bibr92-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm538"},{"key":"bibr93-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00721-09"},{"key":"bibr94-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07322-4"},{"key":"bibr95-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.04.013"},{"key":"bibr96-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.10.011"},{"key":"bibr97-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.541439"},{"key":"bibr98-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02921.x"},{"key":"bibr99-2049936113476284","author":"Mir\u00f3 E.","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"bibr100-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/657135"},{"key":"bibr101-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2010.05.002"},{"key":"bibr102-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.08.018"},{"key":"bibr103-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701367801"},{"key":"bibr104-2049936113476284","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110655"},{"key":"bibr105-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3720-3728.2004"},{"key":"bibr106-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05650-11"},{"key":"bibr107-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.28"},{"key":"bibr108-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2006.05.238"},{"key":"bibr109-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.657-686.2005"},{"key":"bibr110-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.6.2206-2212.2001"},{"key":"bibr111-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq069"},{"key":"bibr112-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-245"},{"key":"bibr113-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00143-07"},{"key":"bibr114-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3311-3316.2005"},{"key":"bibr115-2049936113476284","doi-asserted-by":"publisher","DOI":"10.2165\/11533040-000000000-00000"},{"key":"bibr116-2049936113476284","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811306020257"},{"key":"bibr117-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.04.023"},{"key":"bibr118-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.15-22.2004"},{"key":"bibr119-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.10.031"},{"key":"bibr120-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis270"},{"key":"bibr121-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm443"},{"key":"bibr122-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06268-11"},{"key":"bibr123-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00462-11"},{"key":"bibr124-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00862-10"},{"key":"bibr125-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.08.020"},{"key":"bibr126-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1038\/nm1347"},{"key":"bibr127-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03482.x"},{"key":"bibr128-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.17.1897"},{"key":"bibr129-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.11.016"},{"key":"bibr130-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir790"},{"key":"bibr131-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.6.5.671"},{"key":"bibr132-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/649537"},{"key":"bibr133-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03673.x"},{"key":"bibr134-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr423"},{"key":"bibr135-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir273"},{"key":"bibr136-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks065"},{"key":"bibr137-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg222"},{"key":"bibr138-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01737-10"},{"key":"bibr139-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01020-07"},{"key":"bibr140-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2010.22.5.355"},{"key":"bibr141-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2011.23.5.263"},{"key":"bibr142-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.10.029"},{"key":"bibr143-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.012468-0"},{"key":"bibr144-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr337"},{"key":"bibr145-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06323.x"},{"key":"bibr146-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00220-10"},{"key":"bibr147-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.08.003"},{"key":"bibr148-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70177-3"},{"key":"bibr149-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1086\/522288"},{"key":"bibr150-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2011.0161"},{"key":"bibr151-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.02.004"},{"key":"bibr152-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3492-3494.2005"},{"key":"bibr153-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01509-06"},{"key":"bibr154-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis588"},{"key":"bibr155-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2012.08.006"},{"key":"bibr156-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.11.004"},{"key":"bibr157-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05035-11"},{"key":"bibr158-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks214"},{"key":"bibr159-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks301"},{"key":"bibr160-2049936113476284","first-page":"S438","volume":"17","author":"Vazquez J.","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"bibr161-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.748653"},{"key":"bibr162-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm193"},{"key":"bibr163-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm317"},{"key":"bibr164-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.02.004"},{"key":"bibr165-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00024-11"},{"key":"bibr166-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00748-08"},{"key":"bibr167-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.09.019"},{"key":"bibr168-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr242"},{"key":"bibr169-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70109-3"},{"key":"bibr170-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00339-07"},{"key":"bibr171-2049936113476284","author":"Yilmaz G.","year":"2012","journal-title":"J Infect Chemother"},{"key":"bibr172-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3442-3447.2003"},{"key":"bibr173-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02301-09"},{"key":"bibr174-2049936113476284","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/jac\/dkp254","volume":"64","author":"Zhanel G.","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"bibr175-2049936113476284","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.06.013"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2049936113476284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2049936113476284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2049936113476284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:56:47Z","timestamp":1777593407000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2049936113476284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,8]]},"references-count":175,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1177\/2049936113476284"],"URL":"https:\/\/doi.org\/10.1177\/2049936113476284","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,8]]}}}