{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:52:08Z","timestamp":1787320328120,"version":"build-2736575974"},"reference-count":147,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    Telavancin (TD-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration (USFDA) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria, including MRSA ( S. aureus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus anginosus group, or Enterococcus faecalis). Telavancin has two proposed mechanisms of action. In vitro, telavancin has a rapid, concentration-dependent bactericidal effect, due to disruption of cell membrane integrity. Telavancin has demonstrable in vitro activity against aerobic and anaerobic Gram-positive bacteria. Telavancin and vancomycin have similar spectra of activity. Gram-negative bacteria are usually non-susceptible to telavancin. Telavancin has been successfully tested in various animal models of bacteremia, endocarditis, meningitis, and pneumonia. Phase II Telavancin versus Standard Therapy for Treatment of Complicated Skin and Soft-Tissue Infections due to Gram-Positive Bacteria (FAST 1 and FAST 2) and phase III [Assessment of Telavancin in Complicated Skin and Skin Structure Infections 1 (ATLAS 1 and ATLAS 2)] clinical trials have been conducted for evaluating telavancin\u2019s efficacy and safety in cSSSIs. Phase III clinical trials have been carried out for evaluating telavancin\u2019s safety and efficacy in nosocomial pneumonia [Assessment of Telavancin for Treatment of Hospital acquired Pneumonia 1 and 2 (ATTAIN 1 and ATTAIN 2)]. A phase II randomized, double-blind, clinical trial has been carried out for evaluating telavancin\u2019s safety and efficacy in uncomplicated S. aureus bacteremia [Telavancin for Treatment of Uncomplicated S. aureus Bacteremia (ASSURE)]. Pacemaker lead\u2013related infective endocarditis due to a vancomycin intermediate S. aureus (VISA) strain (non-daptomycin susceptible) was successfully treated with parenteral telavancin for 8 weeks. Telavancin extensively binds to serum albumin (~93%) and has a relatively small volume of distribution. Telavancin is not biotransformed by any cytochrome P\n                    <jats:sub>450<\/jats:sub>\n                    microsomal enzymes and excreted mainly in the urine. Though well-tolerated, worrisome adverse effects, including renal dysfunction and QTc prolongation are of potential concern. Given its extensive binding to plasma proteins, long half-life, and a long post-antibiotic effect, it represents a promising addition to the therapeutic armamentarium in combating infections caused by resistant Gram-positive pathogens, namely, MRSA.\n                  <\/jats:p>","DOI":"10.1177\/2049936117690501","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T04:16:14Z","timestamp":1488946574000},"page":"49-73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant Gram-positive pathogens"],"prefix":"10.1177","volume":"4","author":[{"given":"Biswadeep","family":"Das","sequence":"first","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayna","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Clinical Pharmacology, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Shillong, Shillong, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasmita","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Computer Science & Engineering, Faculty of Engineering, Manipal University Jaipur, Dehmi Kalan, Jaipur Ajmer Expressway, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,8]]},"reference":[{"key":"bibr1-2049936117690501","first-page":"26","volume":"3","author":"Frere J-M","year":"2016","journal-title":"Drug Target Rev"},{"key":"bibr2-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.07.008"},{"key":"bibr3-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/524891"},{"key":"bibr4-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3101"},{"key":"bibr5-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/533590"},{"key":"bibr6-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2016.03.006"},{"key":"bibr7-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68853-3"},{"key":"bibr8-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0104-4"},{"key":"bibr9-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/374621"},{"key":"bibr10-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3926-3934.2003"},{"key":"bibr11-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.10.3785-3788.2001"},{"key":"bibr12-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00254-06"},{"key":"bibr13-2049936117690501","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0514"},{"key":"bibr14-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1303"},{"key":"bibr15-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.20.2254"},{"key":"bibr16-2049936117690501","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.68535"},{"key":"bibr17-2049936117690501","doi-asserted-by":"publisher","DOI":"10.3201\/eid1506.081312"},{"key":"bibr18-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181e78efc"},{"key":"bibr19-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.1127-1134.2005"},{"key":"bibr20-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01641-07"},{"key":"bibr21-2049936117690501","unstructured":"Food and Drug Administration. FDA labelling information, http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/022110s000lbl.pdf (2009, accessed 15 November 2010)."},{"key":"bibr22-2049936117690501","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.326"},{"key":"bibr23-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.04.006"},{"key":"bibr24-2049936117690501","unstructured":"Vibativ\n                      . South San Francisco, CA: Theravance Inc., http:\/\/www.astellas.us\/docs\/us\/VIBATIV_PI_Final.pdf (2009, accessed 21 April 2014)."},{"key":"bibr25-2049936117690501","volume-title":"Abstract presented at 18th European congress of clinical microbiology and infectious diseases (Abstract S415)","author":"Courvalin P"},{"key":"bibr26-2049936117690501","volume-title":"Paper presented at 46th annual interscience conference on antimicrobial agents and chemotherapy","author":"Breukink EJ"},{"key":"bibr27-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(07)70166-8"},{"key":"bibr28-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01710-08"},{"key":"bibr29-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01609-09"},{"key":"bibr30-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl424"},{"key":"bibr31-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh156"},{"key":"bibr32-2049936117690501","volume-title":"Paper presented at 46th annual interscience conference on antimicrobial agents and chemotherapy","author":"Draghi DC"},{"key":"bibr33-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl235"},{"key":"bibr34-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3602-3604.2003"},{"key":"bibr35-2049936117690501","volume-title":"Paper presented at 46th annual interscience conference on antimicrobial agents and chemotherapy","author":"Thornsberry C"},{"key":"bibr36-2049936117690501","volume-title":"Paper presented at 45th annual interscience conference on antimicrobial agents and chemotherapy","author":"Draghi DC"},{"key":"bibr37-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2149-2152.2004"},{"key":"bibr38-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.5.1370-1374.2000"},{"key":"bibr39-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2452"},{"key":"bibr40-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2003.09.004"},{"key":"bibr41-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.03.004"},{"key":"bibr42-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1919-1922.2001"},{"key":"bibr43-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2002.130032"},{"key":"bibr44-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2564"},{"key":"bibr45-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.1062-1066.2000"},{"key":"bibr46-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.2.219"},{"key":"bibr47-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg130"},{"key":"bibr48-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3447-3450.2000"},{"key":"bibr49-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.839"},{"key":"bibr50-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.3.720"},{"key":"bibr51-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1021\/jm9509556"},{"key":"bibr52-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.6.1508"},{"key":"bibr53-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.7.1745"},{"key":"bibr54-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.770-772.2005"},{"key":"bibr55-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00286-06"},{"key":"bibr56-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2001.13.3.244"},{"key":"bibr57-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.2.179"},{"key":"bibr58-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki007"},{"key":"bibr59-2049936117690501","volume-title":"Paper presented at 43rd annual interscience conference on antimicrobial agents and chemotherapy","author":"Ednie LM"},{"key":"bibr60-2049936117690501","volume-title":"Paper presented at 44th annual interscience conference on antimicrobial agents and chemotherapy","author":"Jones RN"},{"key":"bibr61-2049936117690501","volume-title":"Paper presented at 39th annual interscience conference on antimicrobial agents and chemotherapy","author":"Hackbarth C"},{"key":"bibr62-2049936117690501","volume-title":"Paper presented at 44th annual interscience conference on antimicrobial agents and chemotherapy","author":"Flamm RK"},{"key":"bibr63-2049936117690501","volume-title":"Paper presented at 41st annual meeting of the infectious diseases society of America","author":"Appelbaum PC"},{"key":"bibr64-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2595-2601.2002"},{"key":"bibr65-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.721"},{"key":"bibr66-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.5.781"},{"key":"bibr67-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/38.4.589"},{"key":"bibr68-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1179\/joc.1999.11.2.90"},{"key":"bibr69-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.6.1968-1971.2003"},{"key":"bibr70-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.337-341.2003"},{"key":"bibr71-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/491711"},{"key":"bibr72-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ534"},{"key":"bibr73-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01737-09"},{"key":"bibr74-2049936117690501","volume-title":"Paper presented at 44th annual interscience conference on antimicrobial agents and chemotherapy","author":"Kaniga K"},{"key":"bibr75-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki198"},{"key":"bibr76-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl222"},{"key":"bibr77-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3163-3165.2005"},{"key":"bibr78-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01877-16."},{"key":"bibr79-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.770-773.2006"},{"key":"bibr80-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.10.4344-4346.2005"},{"key":"bibr81-2049936117690501","volume-title":"Paper presented at 46th annual interscience conference on antimicrobial agents and chemotherapy","author":"Anon"},{"key":"bibr82-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.195-201.2005"},{"key":"bibr83-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn273"},{"key":"bibr84-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01244-08"},{"key":"bibr85-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.788-790.2006"},{"key":"bibr86-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00875-07"},{"key":"bibr87-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01110-07"},{"key":"bibr88-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/648438"},{"key":"bibr89-2049936117690501","volume-title":"Program and abstracts of the 48th annual ICAA\/ IDSA 46th annual meeting (Abstract A-1879)","author":"Shaw JP"},{"key":"bibr90-2049936117690501","first-page":"276","volume":"10","author":"Duchin K","year":"2004","journal-title":"Clin Microbiol Infec"},{"key":"bibr91-2049936117690501","first-page":"272","volume":"11","author":"Duchin K","year":"2005","journal-title":"Clin Microbiol Infec"},{"key":"bibr92-2049936117690501","author":"Patel JH","year":"2007","journal-title":"Program and abstracts of the 16th European congress of clinical microbiology and infectious diseases"},{"key":"bibr93-2049936117690501","volume-title":"Proceedings of the 46th interscience conference on antimicrobial agents and chemotherapy","author":"Wong SL"},{"key":"bibr94-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00383-11"},{"key":"bibr95-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.06.064"},{"key":"bibr96-2049936117690501","first-page":"S272","volume":"206","author":"Patrikeeva S","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"bibr97-2049936117690501","unstructured":"European Medicines Agency.\nAssessment report: VIBATIV (Procedure No. EMEA\/H\/C\/1240), http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Public_assessment_report\/human\/001240\/WC500115363.pdf\n(2011, accessed 8 July 2014)."},{"key":"bibr98-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01398-07"},{"key":"bibr99-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.3043-3050.2004"},{"key":"bibr100-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01470-06"},{"key":"bibr101-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp001"},{"key":"bibr102-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm417"},{"key":"bibr103-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00062-10"},{"key":"bibr104-2049936117690501","doi-asserted-by":"publisher","DOI":"10.4236\/jibtva.2012.12003"},{"key":"bibr105-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01266-06"},{"key":"bibr106-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00922-12"},{"key":"bibr107-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn490"},{"key":"bibr108-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00435-07"},{"key":"bibr109-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00908-08"},{"key":"bibr110-2049936117690501","doi-asserted-by":"publisher","DOI":"10.2165\/11534440-000000000-00000"},{"key":"bibr111-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.08.012"},{"key":"bibr112-2049936117690501","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.081228"},{"key":"bibr113-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir308"},{"key":"bibr114-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-252"},{"key":"bibr115-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/429914"},{"key":"bibr116-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.862-867.2006"},{"key":"bibr117-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/587896"},{"key":"bibr118-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.05.012"},{"key":"bibr119-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00471-15"},{"key":"bibr120-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.633511"},{"key":"bibr121-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq031"},{"key":"bibr122-2049936117690501","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1111\/j.1469-0691.2007.01840.x","volume":"14","author":"Rubinstein EGRC","year":"2008","journal-title":"Clin Microbiol Infec"},{"key":"bibr123-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041870"},{"key":"bibr124-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ536"},{"key":"bibr125-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-289"},{"key":"bibr126-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00857-10"},{"key":"bibr127-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1086\/653519"},{"key":"bibr128-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr329"},{"issue":"3","key":"bibr129-2049936117690501","first-page":"127","volume":"36","author":"Plotkin P","year":"2011","journal-title":"Pharm Ther"},{"key":"bibr130-2049936117690501","volume-title":"Paper presented at 3rd international symposium on resistant gram-positive infections","author":"Corey GR"},{"key":"bibr131-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr518"},{"key":"bibr132-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004266620"},{"key":"bibr133-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00427.x"},{"key":"bibr134-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2012-000108"},{"key":"bibr135-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2612-0"},{"key":"bibr136-2049936117690501","unstructured":"Vibativ\n                      . Deerfield, IL: Astellas Pharma, US Inc. 2009."},{"key":"bibr137-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009337133"},{"key":"bibr138-2049936117690501","unstructured":"Astellas Pharma. R & D pipeline, http:\/\/www.astellas.com\/en\/ir\/library\/pdf\/1q2011_rd_en.pdf (2010, accessed 16 November 2010)."},{"key":"bibr139-2049936117690501","unstructured":"European Medicines Agency. Questions and answers on the withdrawal of the marketing application for Vibativ, http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Medicine_QA\/2010\/01\/WC500063819.pdf (2008, accessed 22 November 2010)."},{"key":"bibr140-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-12-22"},{"key":"bibr141-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1201\/b13787-57"},{"key":"bibr142-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.12.006"},{"key":"bibr143-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0389-y"},{"key":"bibr144-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu971"},{"key":"bibr145-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02330-13"},{"key":"bibr146-2049936117690501","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1397040"},{"key":"bibr147-2049936117690501","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00330"}],"updated-by":[{"DOI":"10.1177\/2049936117731199","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2049936117690501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2049936117690501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2049936117690501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:57:06Z","timestamp":1777593426000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2049936117690501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":147,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/2049936117690501"],"URL":"https:\/\/doi.org\/10.1177\/2049936117690501","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}