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The so-called and recently introduced term \u2018acute bacterial skin and skin structure infections\u2019 (ABSSSIs), a cluster of fairly common types of infection, including abscesses, cellulitis, and wound infections, require an immediate effective antibacterial treatment as part of a timely and cautious management. The extreme level of resistance globally to many antibiotic drugs in the prevalent causative pathogens, the presence of risk factors of treatment failure, and the high epidemic of comorbidities (e.g. diabetes and obesity) make the appropriate selection of the antibiotic for physicians highly challenging. The selection of antibiotics is primarily empirical for ABSSSI patients which subsequently can be adjusted based on culture results, although rarely available in outpatient management. There is substantial evidence suggesting that inappropriate antibiotic treatment is given to approximately 20\u201325% of patients, potentially prolonging their hospital stay and increasing the risk of morbidity and mortality. The current review paper discusses the concerns related to the management of ABSSSI and the patient types who are most vulnerable to poor outcomes. It also highlights the key management time-points that treating physicians and surgeons must be aware of in order to achieve clinical success and to discharge patients from the hospital as early as possible.<\/jats:p>","DOI":"10.1177\/2049936117723228","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T06:41:51Z","timestamp":1504161711000},"page":"143-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Management of acute bacterial skin and skin structure infections with a focus on patients at high risk of treatment failure"],"prefix":"10.1177","volume":"4","author":[{"given":"Abraham","family":"Pulido-Cejudo","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hospital General de M\u00e9xico, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Guzm\u00e1n-Gutierrez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital General de M\u00e9xico, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Jalife-Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital General de M\u00e9xico, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ortiz-Covarrubias","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Civil de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Mart\u00ednez-Ordaz","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Centro M\u00e9dico Nacional Siglo XXI, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor Faustino","family":"Noyola-Villalobos","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital Central Militar, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Mauricio","family":"Hurtado-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital General de M\u00e9xico, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"bibr1-2049936117723228","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.081228"},{"key":"bibr2-2049936117723228","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12235"},{"key":"bibr3-2049936117723228","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12463"},{"key":"bibr4-2049936117723228","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.09.006"},{"key":"bibr5-2049936117723228","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2011.034"},{"key":"bibr6-2049936117723228","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq302"},{"key":"bibr7-2049936117723228","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu296"},{"key":"bibr8-2049936117723228","unstructured":"Food and Drug Administration. 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