{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:50:05Z","timestamp":1782514205818,"version":"3.54.5"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Studies of nasopharyngeal secretions serve as reliable surrogate to evaluate the involvement of viruses in acute otitis media (AOM) and upper\/lower respiratory tract infections (URIs\/LRIs). We explored nasopharyngeal viral studies from children with uncomplicated AOM and examined their cost-effectiveness in relation to their age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We identified children aged 0\u20136\u2009years admitted to our pediatrics department in a university-affiliated, secondary hospital with uncomplicated AOM and concurrent URI\/LRI between 2012 and 2017, during October\u2013April, when viral studies are performed. Studies were performed either using antigen detection tests, for respiratory syncytial virus (RSV) and influenza A\/B (2012\u20132016) and for a variety of other common respiratory viruses, utilizing multiplex polymerase chain reaction assays (2017).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 249 children were included (median age: 15\u2009months). In 88 (35%) children, viral studies were positive, most of them in children \u2a7d24\u2009months (78, 89%). RSV was positive in 52 (59%) children, followed by influenza A and B, in 11 (13%) and 5 (6%) children, respectively. First year switch to a molecular assay, 4.5-fold more expensive, resulted in a statistically significant higher yield: 69% positive results in \u2a7d24\u2009months, and 66% in those aged \u2a7d12\u2009months ( p\u2009&lt;\u20090.05). In those \u2a7d24\u2009months, US$23 and US$95 were spent for one positive test in the antigen detection years and the polymerase chain reaction year, respectively, whereas in those &gt;24\u2009months, US$83 and US$878 were invested for one positive test in the same year, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In cost-effectiveness terms, the greatest benefit of nasopharyngeal studies was highest in children \u2a7d24\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2049936119871127","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:40:49Z","timestamp":1574210449000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The yield of respiratory viruses detection testing is age-dependent in children with acute otitis media"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-4376","authenticated-orcid":false,"given":"Tal","family":"Marom","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, 70300, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Fellner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze\u2019ev","family":"Hirschfeld","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzilia","family":"Lazarovitch","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Gavriel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limor","family":"Muallem-Kalmovich","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Pitaro","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Assaf Harofeh Medical Center, Tel Aviv University Sackler School of Medicine, Zerifin, 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