{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:27:36Z","timestamp":1793755656828,"version":"4.6.1"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>A drug\u2013drug interaction (DDI) describes the influence of one drug upon another or the change in a drug\u2019s effect on the body when the drug is taken together with a second drug. A DDI can delay, decrease or enhance absorption or metabolism of either drug. Several antifungal agents have a large number of potentially deleterious DDIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The antifungal drug interactions database https:\/\/antifungalinteractions.org\/was first launched in 2012 and is updated regularly. It is available as web and app versions to allow information on potential drug interactions with antifungals with a version for patients and another for health professionals. A new and updated database and interface with apps was created in 2019. This allows clinicians and patients to rapidly check for DDIs. The database is fully referenced to allow the user to access further information if needed. Currently DDIs for fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, terbinafine, amphotericin B, caspofungin, micafungin and anidulafungin are cross-referenced against 2398 other licensed drugs, a total of nearly 17,000 potential DDIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The database records 541 potentially severe DDIs, 1129 moderate and 1015 mild DDIs, a total of 2685 (15.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>As the online database and apps are free to use, we hope that widespread acceptance and usage will reduce medical misadventure and iatrogenic harm from unconsidered DDIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361211010605","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T14:27:41Z","timestamp":1619792861000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Drug\u2013drug interaction database for safe prescribing of systemic antifungal agents"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-4243","authenticated-orcid":false,"given":"Saarah","family":"Niazi-Ali","sequence":"first","affiliation":[{"name":"Fungal Infection Trust, PO Box 482, Macclesfield, Cheshire SK10 9AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham T.","family":"Atherton","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK"},{"name":"National Aspergillosis Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Walczak","sequence":"additional","affiliation":[{"name":"McCollum Consultants, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Denning","sequence":"additional","affiliation":[{"name":"Manchester Fungal Infection Group, The University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"bibr1-20499361211010605","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw391"},{"key":"bibr2-20499361211010605","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2357-5"},{"key":"bibr3-20499361211010605","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-018-3579-7"},{"key":"bibr4-20499361211010605","first-page":"7927","volume":"303","author":"Gohlar G","year":"2019","journal-title":"Pharm J"},{"key":"bibr5-20499361211010605","volume-title":"Antimicrobial stewardship programmes in health-care facilities in low- and middle-income countries. 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