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Although viral pneumonia increases the risk of invasive fungal infections, it remains unclear whether SARS-CoV-2 infection, immunomodulatory therapy, or a combination of both are responsible for the increased recognition of opportunistic infections in COVID-19 patients. Cases of cryptococcosis have previously been reported following treatment with corticosteroids, interleukin (IL)-6 inhibitors, and Janus kinase (JAK) inhibitors, for patients with autoimmune diseases, but their effect on the immunologic response in patients with COVID-19 remains unknown. Herein, we present the case of a patient with COVID-19 who received high-dose corticosteroids and was later found to have cryptococcosis despite no traditional risk factors. As our case and previous cases of cryptococcosis in patients with COVID-19 demonstrate, clinicians must be suspicious of cryptococcosis in COVID-19 patients who clinically deteriorate following treatment with immunomodulatory therapies.<\/jats:p>","DOI":"10.1177\/20499361211066363","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T07:37:33Z","timestamp":1642232253000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Missed opportunities to identify cryptococcosis in COVID-19 patients: a case report and literature review"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-0195","authenticated-orcid":false,"given":"Daniel B.","family":"Chastain","sequence":"first","affiliation":[{"name":"Department of Clinical & Administrative Pharmacy, College of Pharmacy, University of Georgia, 1000 Jefferson Street, Albany, GA 31701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-8652","authenticated-orcid":false,"given":"Andr\u00e9s F.","family":"Henao-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin C.","family":"Dykes","sequence":"additional","affiliation":[{"name":"Department of Clinical & Administrative Pharmacy, College of Pharmacy, University of Georgia, Albany, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Steele","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Phoebe Putney Memorial Hospital, Albany, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Leigh","family":"Stoudenmire","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Phoebe Putney Memorial Hospital, Albany, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geren M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, John D. 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