{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:33:08Z","timestamp":1777879988438,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Background:<\/jats:title>\n Following the World Health Organization (WHO) recommendations for 4-weekly antenatal intermittent preventive treatment of malaria in pregnancy using sulphadoxine-pyrimethamine (IPTp-SP), there is a need to evaluate the drug performance in order to determine their effectiveness as tools in malaria control policy.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To determine prevalence of cord blood malaria, compliance gap and adverse pregnancy outcomes (anaemia, preterm delivery, spontaneous abortion, intra-uterine foetal death and low birth weight) among antenatal IPTp-SP users compared with non-users.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A cross-sectional analytical study was conducted among consenting 390 participants who were administered a questionnaire, and paired blood samples were collected from the venous blood of participants and neonatal cord immediately after delivery. The participants were categorised as IPTp-SP users and non-users. Adverse pregnancy outcomes were assessed. Neonatal birth weights were also measured within 1 h after delivery. Malaria parasitaemia and anaemia were analysed using standard parasitological and haematological methods of examination. Data were analysed using SPSS version 25 for Windows and\n p<\/jats:italic>\n -value of\u2009<\u20090.05 considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of 390 women, 336 (86.2%) were IPTp-SP users, while 54 (13.8%) were non-users. The compliance gap was 13.8%. Malaria parasitemia in pregnant women (21.7%\n versus<\/jats:italic>\n 53.7%;\n p<\/jats:italic>\n \u2009<\u20090.001) and their babies (12.2%\n versus<\/jats:italic>\n 25.4%;\n p<\/jats:italic>\n \u2009=\u20090.002) were observed for IPTp-SP users and non-users, respectively. The prevalence of maternal anaemia was 27(8.0%) in IPTp-SP users and 5 (9.3%) in non-users (\n p<\/jats:italic>\n \u2009=\u20090.789). Mean parasite density was reduced in IPTp-SP users than in non-users (\n p<\/jats:italic>\n \u2009<\u20090.001). Correlation of birth weight according to their sex showed a weak correlation [correlation coefficient (\n r<\/jats:italic>\n )\u2009=\u20090.027;\n p<\/jats:italic>\n \u2009=\u20090.736]. Pregnant women with preterm delivery, spontaneous abortion, intra-uterine foetal death, and low birth weight were significantly lower (\n p<\/jats:italic>\n \u2009<\u20090.001, for all) in IPTp-SP users compared with non-users.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Although the compliance gap was low, IPTp-SP users had significantly better pregnancy and foetal outcomes compared with non-users. Efforts should be intensified towards achieving total compliance in IPTp-SP usage by pregnant women.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/20499361221122620","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T06:34:28Z","timestamp":1662446068000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of antenatal intermittent preventive treatment for malaria with sulphadoxine-pyrimethamine on peripartum outcomes"],"prefix":"10.1177","volume":"9","author":[{"given":"Isaac Okezie","family":"Godwin","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifeoma Mercy","family":"Ekejindu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-2152","authenticated-orcid":false,"given":"George Uchenna","family":"Eleje","sequence":"additional","affiliation":[{"name":"Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka (Nnewi Campus), P.M.B. 5001, Nnewi, Anambra State, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State 435001, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy Amauche","family":"Ezeagwuna","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-8216","authenticated-orcid":false,"given":"Chigozie Geoffrey","family":"Okafor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arinze Anthony","family":"Onwuegbuna","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osita Samuel","family":"Umeononihu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prisca Obiageli","family":"Godwin","sequence":"additional","affiliation":[{"name":"Department of Nursing, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onyecherelam Monday","family":"Ogelle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Ifeanyichukwu","family":"Ikechebelu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organization. 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