{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:14Z","timestamp":1787019374439,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A vancomycin AUC\/MIC (area under the curve\/minimum inhibitory concentration) of 400\u2013600\u2009mg\u2022h\/L is associated with improved clinical outcomes for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections. Currently, there are still limited studies evaluating the relationship between vancomycin trough and AUC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the correlation between vancomycin trough and AUC\/MIC and determine if trough-guided monitoring is an adequate predictor of AUC\/MIC in the Urban Health population at St Paul\u2019s Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective chart review of 29 patients from November 2019 to February 2021. Patient demographics and laboratory data were collected from electronic medical records. The two-level equation-based approach was used to calculate AUC\/MIC. The proportion of AUC\/MIC values within target (400\u2013600\u2009mg\u2022h\/L) despite subtherapeutic troughs, and the proportion of AUC\/MIC values supratherapeutic when trough is within target (15\u201320\u2009mg\/L) were the primary endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results:<\/jats:title>\n                    <jats:p>\n                      Fifty-seven sets of levels were collected and 75% of vancomycin troughs and AUC\n                      <jats:sub>24<\/jats:sub>\n                      were found to be discordant. When trough was 10\u201314.9\u2009mg\/L, AUC\n                      <jats:sub>24<\/jats:sub>\n                      was\u2009&gt;\u2009400\u2009mg\u2022h\/L in 94% of cases and when trough was 15\u201320\u2009mg\/L, AUC\n                      <jats:sub>24<\/jats:sub>\n                      was\u2009&gt;\u2009600\u2009mg\u2022h\/L in 69% of cases. There was a moderate correlation between vancomycin trough and AUC\n                      <jats:sub>24h<\/jats:sub>\n                      ( R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.57; p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A vancomycin trough between 15 and 20\u2009mg\/L may result in an AUC\/MIC greater than necessary for clinical efficacy. Considering these findings and the practical concerns of AUC-guided monitoring, a modest reduction in target troughs to prevent vancomycin toxicity warrants clinical consideration and further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361221140368","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:15:05Z","timestamp":1669688105000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Vancomycin area under the curve\/minimum inhibitory concentration and trough level concordance\u2013evaluation on an urban health unit"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-6547","authenticated-orcid":false,"given":"Maggie","family":"Chen","sequence":"first","affiliation":[{"name":"Pharmacy Department, Vancouver General Hospital, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Lee","sequence":"additional","affiliation":[{"name":"Pharmacy Department, St. Paul\u2019s Hospital, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Gnyra","sequence":"additional","affiliation":[{"name":"Pharmacy Department, St. Paul\u2019s Hospital, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Wong","sequence":"additional","affiliation":[{"name":"Pharmacy Department, St. Paul\u2019s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"bibr1-20499361221140368","unstructured":"Vancomycin. Canadian Pharmacists Association, Ottawa, ON, Canada, 2020."},{"key":"bibr2-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1310\/hpj4409-751"},{"key":"bibr3-20499361221140368","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/jpids\/piaa057","volume":"9","author":"Rybak M","year":"2020","journal-title":"J Pediatr Infect Dis Soc"},{"key":"bibr4-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077169"},{"key":"bibr5-20499361221140368","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"bibr6-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2252-7"},{"key":"bibr7-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01568-12"},{"key":"bibr8-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01653-13"},{"key":"bibr9-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1086\/600884"},{"key":"bibr10-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02535-16"},{"key":"bibr11-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000359"},{"key":"bibr12-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000622"},{"key":"bibr13-20499361221140368","volume":"92","author":"Issaranggoon Na","year":"2020","journal-title":"Int J Infect Dis"},{"key":"bibr14-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03147-14"},{"key":"bibr15-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01293-17"},{"key":"bibr16-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxz070"},{"key":"bibr17-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.016"},{"key":"bibr18-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"bibr19-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00173-11"},{"key":"bibr20-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.06.022"},{"key":"bibr21-20499361221140368","doi-asserted-by":"publisher","DOI":"10.1177\/0897190016642692"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361221140368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361221140368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361221140368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:59:09Z","timestamp":1777593549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361221140368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":21,"alternative-id":["10.1177\/20499361221140368"],"URL":"https:\/\/doi.org\/10.1177\/20499361221140368","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"20499361221140368"}}