{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:33:42Z","timestamp":1777880022738,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Millions of snake bites occur worldwide each year. Clinical practice guidelines generally do not recommend the use of prophylactic antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the sociodemographic, clinical, and pharmacological variables and the use of antibiotics in a group of patients with snake bites in Colombia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study was carried out. Patients affiliated with a Colombian health insurer who presented with snake bites between 2015 and 2022 were included. The cases were identified from the National Public Health Surveillance System. Sociodemographic, clinical and pharmacological variables were identified. Descriptive and bivariate analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 643 patients were analyzed, with a median age of 30.8\u2009years, and 74.7% were men. The most frequently identified genus of snake was Bothrops (88.8%), and most incidents were classified as mild ophidian accidents (61.6%). A total of 59.7% of patients received snake antivenom. A total of 13.8% and 2.2% of the patients had cellulitis or abscesses, respectively. A total of 63.5% received antibiotics (50.6% for prophylaxis and 12.9% for treatment), especially cephalexin (25.9%), and most of the antibiotic management was considered inappropriate (91.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Most patients with snake bites received antibiotics, especially for prophylactic purposes, a clinical behavior that goes against current evidence. The use of antibiotics with an unsuitable spectrum for the microorganisms that are usually found in the wounds of these patients is frequent. The development of local clinical practice guidelines is required to help reduce the overprescription of antibiotics, as the excessive use of antimicrobials is the main determinant of antimicrobial resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361231210400","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T03:54:33Z","timestamp":1699502073000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics and use of antibiotics in a group of patients with snake bites in Colombia"],"prefix":"10.1177","volume":"10","author":[{"given":"Luis Fernando","family":"Valladales-Restrepo","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Farmacoepidemiolog\u00eda y Farmacovigilancia, Universidad Tecnol\u00f3gica de Pereira-Audifarma S.A., Pereira, Risaralda, Colombia"},{"name":"Grupo de Investigaci\u00f3n Biomedicina, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Colombia"},{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Sofia","family":"Rojas-Ramirez","sequence":"additional","affiliation":[{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melba Jasbleidy","family":"Santander-Pai","sequence":"additional","affiliation":[{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Lozada-Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Valentina","family":"Bedoya-Duque","sequence":"additional","affiliation":[{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayana Yuliet","family":"Sabogal-Sanchez","sequence":"additional","affiliation":[{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas Stiven","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Semillero de Investigaci\u00f3n en Farmacolog\u00eda Geri\u00e1trica, Facultad de Medicina, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas, Pereira, Risaralda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-0936","authenticated-orcid":false,"given":"Jorge Enrique","family":"Machado-Alba","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Farmacoepidemiolog\u00eda y Farmacovigilancia, Universidad Tecnol\u00f3gica de Pereira-Audifarma S.A, Calle 105 # 14-140, Pereira, Risaralda 660003, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"bibr1-20499361231210400","unstructured":"Colombia. Instituto Nacional de Salud. Protocolo de Vigilancia en Salud P\u00fablica de Accidente Of\u00eddico. Versi\u00f3n 4. [Internet], https:\/\/www.ins.gov.co\/buscador-eventos\/Paginas\/Fichas-y-Protocolos.aspx (2022, accessed 7 March 2023)."},{"key":"bibr2-20499361231210400","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.63"},{"key":"bibr3-20499361231210400","unstructured":"World Health Organization. Newsroom. Fact sheets. Snakebite enevenoming 2021, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/snakebite-envenoming (2021, accessed 7 March 2023)."},{"key":"bibr4-20499361231210400","doi-asserted-by":"publisher","DOI":"10.15446\/rsap.v22n3.87005"},{"key":"bibr5-20499361231210400","unstructured":"Instituto Nacional de Salud. Informe evento de accidente of\u00eddico. Colombia, Bogot\u00e1, https:\/\/www.ins.gov.co\/buscador-eventos\/Paginas\/Info-Evento.aspx (2022, accessed 7 March 2023)."},{"key":"bibr6-20499361231210400","unstructured":"World Health Organization. Guidelines for the management of snakebites, 2nd ed, https:\/\/apps.who.int\/iris\/handle\/10665\/249547 (2016, accessed 7 March 2023)."},{"key":"bibr7-20499361231210400","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005745"},{"key":"bibr8-20499361231210400","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/traa062"},{"key":"bibr9-20499361231210400","doi-asserted-by":"crossref","first-page":"314","DOI":"10.7705\/biomedica.5853","volume":"41","author":"Sevilla-S\u00e1nchez MJ","year":"2021","journal-title":"Biomedica"},{"key":"bibr10-20499361231210400","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.154005"},{"key":"bibr11-20499361231210400","unstructured":"World Health Organization. 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