{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:33:45Z","timestamp":1777880025584,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI168609"],"award-info":[{"award-number":["U01AI168609"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Schistosomiasis contributes to 2.5\u2009million disability-adjusted life years globally. Acute and chronic respiratory morbidity of Schistosoma mansoni ( S. mansoni) is poorly documented in the literature. We conducted a rapid literature review of the burden of respiratory symptoms and lung function abnormalities among patients with S. mansoni. We also report the immunologic and lung imaging findings from the studies reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 2243 patients with S. mansoni were reported from 24 case reports, 11 cross-sectional studies, 7 case series, 2 cohort studies and 2 randomized controlled trials. The prevalence of any respiratory symptom was 13.3\u201363.3% (total number of patients studied, n\u2009=\u2009149). The prevalence of the individual symptoms among patients with S. mansoni in whom respiratory symptoms were sought for was as follows: cough (8.3\u201380.6%, n\u2009=\u2009338), dyspnea (1.7\u2013100.0%, n\u2009=\u2009200), chest pain (9.0\u201357.1%, n\u2009=\u200986), sputum production (20.0\u201323.3%, n\u2009=\u200930) and wheezing (0.0\u2009\u2013\u200920.0%, n\u2009=\u20091396). The frequency of the symptoms tended to be higher in acute schistosomiasis. Restrictive lung disease was prevalent in 29.0% (9\/31). The commonest chest imaging findings reported were nodules (20\u201390%, n\u2009=\u2009103) and interstitial infiltrates (12.5\u201323.0%, n\u2009=\u200989). Peripheral blood eosinophilia was prevalent in 72.0\u2013100.0% of patients ( n\u2009=\u2009130) with acute schistosomiasis and correlated with symptoms and imaging abnormalities. Three case reports in chronic S. mansoni reported elevated C-reactive protein, leucocyte, neutrophil and absolute eosinophil counts, eosinophil percentage, IgE and IgG4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a high prevalence of respiratory morbidity among patients with S. mansoni, particularly in the acute stage of the infection, although the studies are relatively small. Larger studies are needed to characterize respiratory morbidity in chronic schistosomiasis and determine the underlying clinical and immunological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361231220152","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T01:32:32Z","timestamp":1703554352000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory morbidity in\n                    <i>Schistosoma mansoni<\/i>\n                    infection: a rapid review of literature"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5852-9674","authenticated-orcid":false,"given":"Joseph Baruch","family":"Baluku","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Programme, MRC\/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda"},{"name":"Department of Internal Medicine, Makerere University College of Health Sciences, PO Box 26343, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-0111","authenticated-orcid":false,"given":"Ronald","family":"Olum","sequence":"additional","affiliation":[{"name":"St. Francis Hospital, Nsambya, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Sanya","sequence":"additional","affiliation":[{"name":"Immunomodulation and Vaccines Programme, MRC\/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda"},{"name":"Chronic Diseases Management Unit, African Population and Health Research Center, Nairobi, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponsiano","family":"Ocama","sequence":"additional","affiliation":[{"name":"Immunomodulation and Vaccines Programme, MRC\/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda"},{"name":"Department of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"key":"bibr1-20499361231220152","unstructured":"World Health Organization. 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