{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:33:51Z","timestamp":1777880031531,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Cryptococcal infections, though rare, must be considered in all immunocompromised patients. Patients with HIV\/AIDS on antiretrovirals may have a treatment course complicated by immune reconstitution inflammatory syndrome. Here we present a case of a 38-year-old woman with HIV\/AIDS with knee pain who only began to experience severe pain after induction of antiretroviral therapy. She was found to have cryptococcal osteomyelitis without dissemination to the central nervous system, an unusual presentation for immunocompromised patients. She was treated with oral fluconazole with a resolution of symptoms. This case report suggests conservative management of isolated cryptococcal infection with fluconazole, regardless of immune status.<\/jats:p>","DOI":"10.1177\/20499361241230149","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:16:58Z","timestamp":1707275818000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Isolated cryptococcal osteomyelitis in the setting of immune reconstitution inflammatory syndrome"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-648X","authenticated-orcid":false,"given":"Pamela","family":"Horton Embrey","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Long","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Alfattal","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suimin","family":"Qiu","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-6880","authenticated-orcid":false,"given":"Joseph Patrik","family":"Hornak","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"bibr1-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.6"},{"key":"bibr2-20499361241230149","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.859049"},{"key":"bibr3-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.006"},{"key":"bibr4-20499361241230149","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122419"},{"key":"bibr5-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2021.12.004"},{"key":"bibr6-20499361241230149","volume-title":"Management of immune reconstitution inflammatory syndrome (IRIS)","author":"Brust JCM","year":"2021"},{"key":"bibr7-20499361241230149","first-page":"740","volume":"5","author":"Heng-Xing Z","year":"2015","journal-title":"Front Microbiol"},{"key":"bibr8-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12476"},{"key":"bibr9-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"bibr10-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-020-00924-4"},{"key":"bibr11-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710922"},{"key":"bibr12-20499361241230149","doi-asserted-by":"publisher","DOI":"10.1086\/652652"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241230149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361241230149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241230149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:04Z","timestamp":1777593604000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361241230149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":12,"alternative-id":["10.1177\/20499361241230149"],"URL":"https:\/\/doi.org\/10.1177\/20499361241230149","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20499361241230149"}}