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We describe a case of Apophysomyces infection associated with long-term use of ibrutinib for the treatment of chronic lymphocytic leukemia as well as perform a literature review of Mucormycosis infections in patients on ibrutinib. Our review found that the onset of IFI can occur within months to years of starting tyrosine kinase inhibitors. These reports provide a more complete picture of the risk of IFI while patients are on ibrutinib. Our case also demonstrates the utility of molecular techniques in the diagnosis of IFI, as the diagnosis was made using 28S rDNA\/internal transcribed spacer PCR.<\/jats:p>","DOI":"10.1177\/20499361241241199","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T05:31:23Z","timestamp":1711431083000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ibrutinib-associated cutaneous mucormycosis due to an\n                    <i>Apophysomyces<\/i>\n                    species: report of a case and review of the literature"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-4186","authenticated-orcid":false,"given":"Trung Minh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, 1 Baylor Plz, Houston, TX 77030-3411, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Amenta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX, USA"},{"name":"Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX, USA"},{"name":"Section of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvari","family":"Yellapragada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX, USA"},{"name":"Section of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA"},{"name":"Michael E. 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