{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:33:53Z","timestamp":1777880033518,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015629","name":"Jerome L. Greene Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR070254"],"award-info":[{"award-number":["P30 AR070254"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rheumatology Research Foundation Career Development Funding Award: K Bridge"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anti-annexin A2 (AA2) antibodies have been described in Lyme arthritis and erythema migrans, although they have not been described in post-treatment Lyme disease (PTLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Determine whether anti-AA2 antibodies are present among patients with PTLD and determine the clinical relevance of these antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods:<\/jats:title>\n                    <jats:p>Anti-AA2 levels were tested serially in a longitudinal cohort of 44 patients with acute Lyme disease, 22 with a return to health (EM RTH), and 22 with PTLD. Anti-AA2 antibodies were also assessed in a cross-sectional group of 281 patients with PTLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Anti-AA2 antibodies were highest after antimicrobial therapy in both the EM RTH and PTLD cohorts. By 6\u2009months, there was no difference between EM RTH and healthy controls. Anti-AA2 antibodies were higher in the cross-sectional PTLD group (79.69 versus 48.22\u2009units, p\u2009&lt;\u20090.0001), though with no difference in total symptom burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anti-AA2 persists in PTLD, though did not identify a clinical phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361241242971","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T08:34:35Z","timestamp":1711787675000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Annexin A2 antibodies in post-treatment Lyme disease"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-4413","authenticated-orcid":false,"given":"John B.","family":"Miller","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F Lord Building Center Tower, Suite 4100, Baltimore, MD 21224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison W.","family":"Rebman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Daniela Villegas","family":"de Flores","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Darrah","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Aucott","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"bibr1-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1002\/art.39866"},{"key":"bibr2-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.07.005"},{"key":"bibr3-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018220"},{"key":"bibr4-20499361241242971","doi-asserted-by":"publisher","DOI":"10.3201\/eid2906.221685"},{"key":"bibr5-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.01.033"},{"key":"bibr6-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1086\/508667"},{"key":"bibr7-20499361241242971","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00224"},{"key":"bibr8-20499361241242971","unstructured":"Centers for Disease Control and Prevention. Lyme disease (\n                      Borrelia burgdorferi\n                      ) 2011 case definition, https:\/\/ndc.services.cdc.gov\/case-definitions\/lyme-disease-2011 (2011, accessed 25 September 2023)."},{"key":"bibr9-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9188-1"},{"key":"bibr10-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2636"},{"key":"bibr11-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1708"},{"key":"bibr12-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311414098"},{"key":"bibr13-20499361241242971","volume":"132","author":"Gwynne PJ","year":"2022","journal-title":"Borrelia burgdorferi. J Clin Invest"},{"key":"bibr14-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28209"},{"key":"bibr15-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00918-2021"},{"key":"bibr16-20499361241242971","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080957"},{"key":"bibr17-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12839-5"},{"key":"bibr18-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16238"},{"key":"bibr19-20499361241242971","doi-asserted-by":"publisher","DOI":"10.1159\/000443519"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241242971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361241242971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241242971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:16Z","timestamp":1777593616000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361241242971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":19,"alternative-id":["10.1177\/20499361241242971"],"URL":"https:\/\/doi.org\/10.1177\/20499361241242971","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20499361241242971"}}