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In immunocompromised patients, the course of the infection can be more serious because of the suppressed antibacterial response, causing a life-threatening disease. A 54-year-old male patient presented with ulcerative colitis. Five days after receiving the first dose of infliximab 400\u2009mg intravenously and 0.5\u2009mg\/kg methylprednisolone, he presented with enlarged axillary lymph nodes and colliquation of the intraabdominal lymph node with intrahepatic colliquating areas caused by B. henselae after cat bites. Long-term treatment with multiple antibiotics and prednisolone resulted in clinical improvement and regression of the liver and intra-abdominal lymph nodes. After further treatment for ulcerative colitis, we assessed the possibility of reintroducing immunosuppressive therapy. Adalimumab was introduced after consulting an infectious disease specialist. At the follow-up visit, the patient was in remission of ulcerative colitis and without signs of reactivation of bartonellosis. Diseases such as CSD with a benign clinical appearance and prognosis can develop a severe and life-threatening course in immunocompromised patients. This requires a complex understanding of the immune processes in such patients, and the reintroduction of immunosuppressive therapy after successful treatment of CSD probably does not increase the risk of reactivation.<\/jats:p>","DOI":"10.1177\/20499361241271832","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T08:32:49Z","timestamp":1731054769000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of generalized cat scratch disease in a patient with ulcerative colitis on immunosuppressive therapy"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-6698","authenticated-orcid":false,"given":"Bruna","family":"Ro\u0161i\u0107 Despalatovi\u0107","sequence":"first","affiliation":[{"name":"\u201cJ&J MEDICI\u201d Polyclinic for Internal Medicine, Split, 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