{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:12:22Z","timestamp":1787508742750,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"beta discoveric bio","award":["SON00613"],"award-info":[{"award-number":["SON00613"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bacterial infections frequently occur in haematological patients, especially during prolonged neutropenia after intensive chemotherapy, often leading to bloodstream infections and pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Routine antimicrobial prophylaxis (AMP) for high-risk haematology patients is still debated while prevalence of multi-drug resistant (MDR) Gram-negative bacteria (GNB) is rising globally. We aimed to assess the current practice of AMP in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional observational survey study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Haematologists and infectious diseases physicians Europewide were invited to an online survey including questions on routine screening for GNB, incidence of MDR-GNB colonization, antimicrobial prophylaxis practices, rates of bloodstream infections (BSI), ICU admission and mortality differentiated by infections due to GNB versus MDR-GNB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>120 haematology centres from 28 countries participated. Screening for MDR-GNB is performed in 86.7% of centres, mostly via rectal swabs (58.3%). In 39.2% of routine AMP is used, mostly with fluoroquinolones. Estimates of GNB-BSI yielded higher rates in patients not receiving anti-GNB prophylaxis than in those who do for E. coli (10% vs 7%) Klebsiella spp. (10% vs 5%), and Pseudomonas spp. (5% vs 4%). Rates for MDR-GNB infection were estimated lower in centres that administer AMP for MDR E. coli (5% vs 3%) Klebsiella spp. (5% vs 3%), and Pseudomonas spp. (2% vs 1%). In an exploratory analysis, Southern and Eastern European countries expected higher rates of MDR-GNB infections with lower ICU admission and mortality rates which may be subject to estimation bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Screening for MDR-GNB is frequently performed. AMP against GNB infections is still often implemented. Estimated BSI rates are rather low, while the rate of MDR-GNB infections rises. Tailored prophylaxis including antimicrobial stewardship becomes more important.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361241271863","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T11:36:52Z","timestamp":1730201812000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Current practice of screening and antimicrobial prophylaxis to prevent Gram-negative bacterial infection in high-risk haematology patients: results from a pan-European survey"],"prefix":"10.1177","volume":"11","author":[{"given":"Jannik","family":"Stemler","sequence":"first","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine, and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Gavriilaki","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Hlukhareva","sequence":"additional","affiliation":[{"name":"Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of Cherkasy Oblast Council, Cherkasy, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, Departments of Biomedicine, University Hospital and University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysios","family":"Neofytos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Transplant Infectious Disease Service, University Hospital of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Akova","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Miguel","family":"Cisneros","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Microbiology and Parasitology, Virgen del Roc\u00edo University Hospital, Institute of Biomedicine of Seville (IBiS), CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine, and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany"},{"name":"University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS K\u00f6ln), Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-8297","authenticated-orcid":false,"given":"Jon","family":"Salmanton-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine, and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Herderstra\u00dfe 52, Cologne 50931, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"bibr1-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.idh.2019.08.006"},{"key":"bibr2-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06884-2"},{"key":"bibr3-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1082"},{"key":"bibr4-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00374"},{"key":"bibr5-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30056-1"},{"key":"bibr6-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04452-9"},{"key":"bibr7-20499361241271863","unstructured":"European Center for Disease Prevention and Control. Surveillance Atlas of Infectious Diseases. European Center for Disease Prevention and Control. Stockholm, Sweden, http:\/\/atlas.ecdc.europa.eu\/public\/index.aspx (2022, accessed 2023)."},{"key":"bibr8-20499361241271863","doi-asserted-by":"publisher","DOI":"10.3201\/eid1806.110139"},{"key":"bibr9-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1086\/521260"},{"key":"bibr10-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.12.005"},{"key":"bibr11-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1506-5"},{"key":"bibr12-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy768"},{"key":"bibr13-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.06.007"},{"key":"bibr14-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix824"},{"key":"bibr15-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix270"},{"key":"bibr16-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv423"},{"key":"bibr17-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku305"},{"key":"bibr18-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01474"},{"key":"bibr19-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044097"},{"key":"bibr20-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050078"},{"key":"bibr21-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283630dd3"},{"key":"bibr22-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2023.07.010"},{"key":"bibr23-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00079-17"},{"key":"bibr24-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08853-3"},{"key":"bibr25-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22205"},{"key":"bibr26-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00270-4"},{"key":"bibr27-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.10.009"},{"key":"bibr28-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00811-8"},{"key":"bibr29-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.12.029"},{"key":"bibr30-20499361241271863","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.2.2001876"},{"key":"bibr31-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.04.027"},{"key":"bibr32-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.04.257"},{"key":"bibr33-20499361241271863","first-page":"1571","volume":"310","author":"Harris AD","year":"2013","journal-title":"Jama"},{"key":"bibr34-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000373"},{"key":"bibr35-20499361241271863","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2017.08.031"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241271863","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361241271863","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241271863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:32Z","timestamp":1777593632000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361241271863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"alternative-id":["10.1177\/20499361241271863"],"URL":"https:\/\/doi.org\/10.1177\/20499361241271863","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20499361241271863"}}