{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:10Z","timestamp":1777880050176,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>We describe a group of four travelers returning to the United States and Canada who acquired Leishmania braziliensis infection in the Peruvian Amazon. Pentavalent antimonials are the preferred treatment option for cutaneous leishmaniasis (CL) in most endemic countries in Central and South America. However, we initially treated our patients with liposomal amphotericin B (LAB) and miltefosine since these are the only two available Food and Drug Administration approved drugs in the United States. Refractory disease was common as three of the four travelers required repeated courses of miltefosine and two also received LAB. One patient required intravenous therapy with meglumine antimoniate (NMG), and one received intralesional NMG. Given the increasing number of cases of CL identified in the United States, there is an urgent need for expanded access to pentavalent antimonials for treating leishmaniasis acquired in Central and South America.<\/jats:p>","DOI":"10.1177\/20499361241274254","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T06:59:12Z","timestamp":1731740352000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges in the treatment of cutaneous leishmaniasis caused by\n                    <i>L. braziliensis<\/i>\n                    in four travelers: a case series"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1343-5092","authenticated-orcid":false,"given":"Carolina","family":"Moreira Sarmiento","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases at Mount Sinai Morningside\/West, 419 W 114th St, Floor 13, New York, NY 10025, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Crowder","sequence":"additional","affiliation":[{"name":"Franciscan Health Travel Well, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Meatherall","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Bezemer","sequence":"additional","affiliation":[{"name":"Hospital del d\u00eda Shell, Fundaci\u00f3n Misi\u00f3n Cristiana de Salud, Canton Mera, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenjean","family":"Hwang","sequence":"additional","affiliation":[{"name":"Alta Bates Summit Medical Center, Oakland, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases at Mount Sinai Morningside\/West, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Mumtaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology at Mount Sinai Hospital, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases at Mount Sinai Morningside\/West, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan David","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine at Mount Sinai Hospital, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Paniz-Mondolfi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular and Cell-Based Medicine at Mount Sinai Hospital, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Franco-Paredes","sequence":"additional","affiliation":[{"name":"Hospital Infantil de Mexico, Federico Gomez, Fort Collins, CO, Mexico"},{"name":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valida","family":"Bajrovic","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases at Mount Sinai Morningside\/West, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"bibr1-20499361241274254","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"bibr2-20499361241274254","volume":"9","author":"Unterborn R","year":"2022","journal-title":"Ther Adv Infect Dis"},{"key":"bibr3-20499361241274254","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-0086"},{"key":"bibr4-20499361241274254","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.993338"},{"key":"bibr5-20499361241274254","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011029"},{"key":"bibr6-20499361241274254","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00726-8"},{"key":"bibr7-20499361241274254","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw742"},{"key":"bibr8-20499361241274254","unstructured":"Makin S. A nasty tropical skin disease is now endemic in the U.S. Scientific American, https:\/\/www.scientificamerican.com\/article\/a-nasty-tropical-skin-disease-is-now-endemic-in-the-u-s\/ (2023)."},{"key":"bibr9-20499361241274254","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00030-11"},{"key":"bibr10-20499361241274254","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006094"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241274254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361241274254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361241274254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:37Z","timestamp":1777593637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361241274254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":10,"alternative-id":["10.1177\/20499361241274254"],"URL":"https:\/\/doi.org\/10.1177\/20499361241274254","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"20499361241274254"}}