{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:15Z","timestamp":1777880055583,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Reduced or delayed access to medical resources on weekends could lead to worsening outcomes, in critically ill infected patients requiring intensive care unit (ICU) admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the \u201cweekend effect,\u201d on critically ill infected patients in Japanese ICUs for the first time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Multicenter retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We examined data from Japanese ICU patients participating in the DIANA study, a multicenter international observational cohort study. This prospective investigation enrolled critically ill patients with infections admitted to the ICU. The primary endpoint was successful discharge from the ICU within 28 days of admission. Outcome measures were evaluated through both univariate and covariate Cox regression analyses, providing hazard ratios (HRs) along with estimated 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of the 276 patients enrolled in the DIANA study across 31 facilities, 208 patients (75.4%) meeting the inclusion criteria were included in the analysis. The weekday ICU admission group comprised 156 patients (75.0%), while the weekend ICU admission group comprised 52 patients (25.0%). In the multivariate Cox regression analysis, there were no statistically significant differences observed in the rates of ICU discharge alive within 28 days and 14 days (28 days, HR: 0.94, 95% CI: 0.63\u20131.40; 14 days, HR: 0.97, 95% CI: 0.64\u20131.48). Furthermore, the overall ICU mortality rates at 28 days and 14 days after ICU admission did not show statistical significance between patients admitted on weekends and those admitted on weekdays (ICU mortality, 28 days: 13.5% vs 11.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.806; 14 days: 7.7% vs 10.9%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.604).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The rates of ICU discharge alive within 28 days after ICU admission did not differ significantly between weekday and weekend admissions, both in the unadjusted and adjusted analyses. Moreover, further well-designed studies are warranted to thoroughly assess this effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361241292626","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T05:06:48Z","timestamp":1748408808000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The weekend effect in critically ill patients with severe infections in Japanese intensive care units: a multicenter retrospective cohort study"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-1230","authenticated-orcid":false,"given":"Teiko","family":"Kawahigashi","sequence":"first","affiliation":[{"name":"Department of Hematology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa 247-8533, Japan"},{"name":"Department of Critical Care Medicine, Shonan Kamakura General Hospital, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, TKG Muneoka Central Hospital, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"De Waele","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium"},{"name":"Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbet","family":"De Bus","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium"},{"name":"Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Takaba","sequence":"additional","affiliation":[{"name":"JA Hiroshima General Hospital, Hatsukaichi, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-4031","authenticated-orcid":false,"given":"Akira","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Kurashiki Central Hospital, Kurashiki, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Takarazuka City Hospital, Takarazuka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Nippon Medical School Tama Nagayama Hospital, Tama, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hashi","sequence":"additional","affiliation":[{"name":"Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital, Hitachi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nashiki","sequence":"additional","affiliation":[{"name":"Iwate Prefectural Central Hospital, Morioka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, Wakayama Medical University Hospital, Wakayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-5550","authenticated-orcid":false,"given":"Masafumi","family":"Kanamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Gunma Prefectural Cardiovascular Center, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nagoya City University Hospital, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinshu","family":"Katayama","sequence":"additional","affiliation":[{"name":"Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiomi","family":"Kawagishi","sequence":"additional","affiliation":[{"name":"Toyama University Hospital, Toyama-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Kawano","sequence":"additional","affiliation":[{"name":"Fukuoka University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Fujita","sequence":"additional","affiliation":[{"name":"Aichi Medical University Hospital, Nagakute, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Emergency Medicine, Hiroshima Red Cross Hospital &amp; Atomic-bomb Survivors Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Hara","sequence":"additional","affiliation":[{"name":"Yodogawa 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