{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:31:34Z","timestamp":1791469894050,"version":"4.3.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Coordination for the Improvement of Higher Education Personnel of Brazil"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infectious and parasitic diseases (IPDs) encompass a broad range of illnesses predominantly associated with poverty. They are more prevalent in low- and middle-income countries, including Brazil, where they continue to be among the leading causes of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to analyze the spatiotemporal dynamics of mortality due to IPDs in Brazil from 2000 to 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted an ecological study using data on mortality by IPDs from the Brazilian Mortality Information System. We applied the segmented log-linear regression model to assess temporal trends. For spatial analysis, we used the local empirical Bayesian estimator and Moran indices. Retrospective spatiotemporal scan statistics were performed using the Poisson Probability Distribution Model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Between 2000 and 2019, there were 2,155,513 deaths related to IPDs in Brazil. The leading causes of death included acute respiratory infections ( n\u2009=\u20091,130,069; 52.49%), septicemia ( n\u2009=\u2009289,817; 13.46%), human immunodeficiency virus\/acquired immunodeficiency syndrome ( n\u2009=\u2009232,892; 10.82%), tuberculosis ( n\u2009=\u2009104,121; 4.84%), and neglected tropical diseases such as Chagas disease ( n\u2009=\u200994,788; 4.40%) and schistosomiasis ( n\u2009=\u200910,272; 0.48%). An increasing temporal trend in the mortality rate from IPDs was observed in Brazil and across all its regions. Additionally, our spatiotemporal scan identified high-risk clusters of death in the Southeast and Northeast regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mortality from IPDs remains a significant public health concern in Brazil, with an increasing trend observed in all regions. Our findings underscore the urgent need for comprehensive intersectoral public policies. These policies should focus on a greater allocation of resources and investments in the most critical areas, aiming to significantly reduce the number of deaths, particularly in the most vulnerable regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251313830","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:08:42Z","timestamp":1738303722000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Spacetime modeling of mortality by infectious and parasitic diseases in Brazil: a 20-year ecological and population-based study"],"prefix":"10.1177","volume":"12","author":[{"given":"Lucas Almeida","family":"Andrade","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences, Universidade Federal de Sergipe, Aracaju, SE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Dornels Freire","family":"de Souza","sequence":"additional","affiliation":[{"name":"College of Medicine, Federal University of Vale do S\u00e3o Francisco, Petrolina, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandklebson Silva da","family":"Paz","sequence":"additional","affiliation":[{"name":"Tropical Medicine Graduate Program, Universidade Federal de Pernambuco, Recife, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6223-7634","authenticated-orcid":false,"given":"Danilo de","family":"Gois Souza","sequence":"additional","affiliation":[{"name":"Collective Health Research Center, Federal University of Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Augusto Passos","family":"G\u00f3es","sequence":"additional","affiliation":[{"name":"Collective Health Research Center, Federal University of Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Lucas Silva","family":"Camargo","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-2122","authenticated-orcid":false,"given":"\u00c1lvaro Francisco Lopes","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Institute of Teaching and Research, Hospital S\u00edrio-Lib\u00e2nes, Rua Dona Adma Jafet, 115 Bela Vista, S\u00e3o Paulo, SP 01308-050, Brazil"},{"name":"National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, REAL, NOVA University of Lisbon, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-8767","authenticated-orcid":false,"given":"Liliane","family":"Moretti Carneiro","sequence":"additional","affiliation":[{"name":"Program in Health and Development in the Central-West Region, Universidade Federal do Mato Grosso do Sul, Tr\u00eas Lagoas, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-4319","authenticated-orcid":false,"given":"Isabel Am\u00e9lia Costa","family":"Mendes","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto College of Nursing, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Machado Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Universidade Federal de Sergipe, Aracaju, SE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-1887","authenticated-orcid":false,"given":"Allan Dantas dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nursing, Federal University of Sergipe, S\u00e3o Crist\u00f3v\u00e3o, SE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio","family":"Bezerra-Santos","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Universidade Federal de Sergipe, Aracaju, SE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"bibr1-20499361251313830","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0331-3"},{"key":"bibr2-20499361251313830","doi-asserted-by":"publisher","DOI":"10.1186\/s12961-022-00889-0"},{"key":"bibr3-20499361251313830","unstructured":"World Health Organization. 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