{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:26Z","timestamp":1777880066342,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sepsis is one of the leading causes of morbidity and mortality worldwide. Early detection and reliable prediction of sepsis-related mortality are crucial. The prognostic value of National Early Warning Score 2 (NEWS-2) in sepsis patients with cardiovascular and neurovascular diseases is not well elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aims to evaluate and compare the qSOFA, SOFA, qPitt, and NEWS-2 scores for predicting mortality in sepsis and septic shock patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>An observational retrospective study was conducted involving patients with sepsis or septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were collected between 2023 and 2024. Baseline measures included sociodemographic and clinical characteristics. All subjects were identified from a database of a highly complex healthcare institution focused on the diagnosis and treatment of cardiovascular and neurovascular diseases. The scores qSOFA, SOFA, NEWS-2, and qPitt were collected from medical records and analyzed. A sample size was estimated. The area under the receiver operating characteristic curve (AUROC) analysis was established for each score. A multivariate analysis adjusted for confounding factors through logistic regression was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 126 participants were included, with a median age of 72\u2009years (IQR: 59\u201381), and 76 (60.32%) being men. The overall mortality rate in the population was 19.8%, with 84% of deaths occurring in males. Statistically significant differences in variables such as heart failure, mild liver disease, and atrial fibrillation were observed between the groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The NEWS-2 score with a cut-off point of \u2a7e8 showed a significant association with mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0001). The AUROC for NEWS-2 was 0.80, compared to a ROC of 0.6960 for qPitt, 0.6776 for SOFA, and 0.5868 for qSOFA (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200916.60, Prob\u2009&gt;\u2009\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NEWS 2 exhibits better performance in predicting mortality among elderly adults with cardiovascular and neurovascular diseases suffering from sepsis or septic shock, compared to the qPitt, SOFA, and qSOFA scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251323207","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:18:51Z","timestamp":1742822331000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of mortality in cardio-neurovascular patients with sepsis and septic shock: is NEWS-2 better than qSOFA, SOFA, and qPitt? An observational study"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-7237","authenticated-orcid":false,"given":"Julian Orlando","family":"Casallas-Barrera","sequence":"first","affiliation":[{"name":"Department of Critical Care and Intensive Care Medicine, Fundaci\u00f3n Cl\u00ednica Shaio, Dg. 115a #70c-75, Bogot\u00e1 111121, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlyng Aireth","family":"Zabala-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Critical Care Resident, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Viviana","family":"Aponte-Carrascal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Critical Care Resident, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angie Marcela","family":"Ochoa-Ricardo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Critical Care Resident, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar Felipe","family":"Quintero-Varela","sequence":"additional","affiliation":[{"name":"Hospitalization Department, Fundaci\u00f3n Cl\u00ednica Shaio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Nicolas","family":"Qui\u00f1ones-Romero","sequence":"additional","affiliation":[{"name":"Exploratorium Group, Fundaci\u00f3n Cl\u00ednica Shaio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-0929","authenticated-orcid":false,"given":"Jenny Paola","family":"Garz\u00f3n-Ruiz","sequence":"additional","affiliation":[{"name":"Research Department, Fundaci\u00f3n Cl\u00ednica Shaio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Silva-Monsalve","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Fundaci\u00f3n Cl\u00ednica Shaio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Buitrago-Bernal","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Intensive Care Medicine, Fundaci\u00f3n Cl\u00ednica Shaio, Bogot\u00e1, Colombia"},{"name":"Exploratorium Group, Fundaci\u00f3n Cl\u00ednica Shaio, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211133"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/epidemiologia5030032"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06151-x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002255"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2022.05.003"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000330"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0275OC"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415236"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.2147\/IDR.S304952","article-title":"Prognostic accuracy of SOFA, qSOFA, and SIRS for mortality among emergency department patients with infections","volume":"14","author":"Abdullah SO Bin","year":"2021","unstructured":"Abdullah SO Bin, S\u00f8rensen RH, Nielsen FE. 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