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Iron deficiency anemia is the hallmark of chronic, moderate-to-heavy-intensity infections, promoting a vicious poverty cycle. Overt severe and acute life-threatening lower gastrointestinal hemorrhage is an extremely rare manifestation of hookworm infection, as well as finding multiple nematodes attached to the colonic mucosae. This rare hookworm presentation with hematochezia from the colon in a patient living with human immunodeficiency virus highlights the importance of physicians\u2019 awareness of this neglected tropical disease responsible for high morbidity and burden in healthcare systems of endemic regions.\n                  <\/jats:p>","DOI":"10.1177\/20499361251332148","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:55:34Z","timestamp":1747724134000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Not your typical hookworm infection\u2014a case report from the Peruvian Amazon and review of the literature"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-0839","authenticated-orcid":false,"given":"Edgar A.","family":"Ramirez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Universidad Nacional de la Amazon\u00eda Peruana (UNAP), Pasaje bocanegra 54, Iquitos, Seleccionar Estado 065, Per\u00fa"},{"name":"Department of Infectious and Tropical Diseases, Hospital Regional de Loreto \u201cFelipe Santiago Arriola Iglesias\u201d, Iquitos, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricci A.","family":"Chafloque-Vasquez","sequence":"additional","affiliation":[{"name":"PNP \u201cLuis N. 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