{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:36Z","timestamp":1777880076776,"version":"3.51.4"},"reference-count":153,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Central Guidance Fund for Local Science and Technology Development","award":["2024ZY01054"],"award-info":[{"award-number":["2024ZY01054"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022ZFJH003"],"award-info":[{"award-number":["2022ZFJH003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Severe fever with thrombocytopenia syndrome (SFTS) is a hemorrhagic fever caused by\n                    <jats:italic toggle=\"yes\">Bandavirus dabieense<\/jats:italic>\n                    . SFTS was first identified in China in 2009 and has been reported since then in neighboring countries and regions. The clinical manifestations of SFTS include fever, thrombocytopenia, and leukocytopenia and are often accompanied by gastrointestinal symptoms and bleeding. In severe cases, patients experience life-threatening immune damage and cytokine storms. Despite nearly 15\u2009years since its discovery, no effective vaccine has been approved. However, significant progress has been achieved in elucidating the mechanisms of host immune responses, accompanied by the clinical implementation of various therapeutic agents. This article provides a comprehensive review of commonly utilized treatments supported by current clinical evidence. Favipiravir has advantages over ribavirin in terms of viral clearance and prognosis. Conventional immunomodulators like interferon, intravenous immunoglobulin, and glucocorticoids have limited effects and may even worsen conditions, whereas novel immunomodulators such as tocilizumab and ruxolitinib have shown potential for improving prognosis. Prophylactic platelet transfusions neither prevent bleeding nor improve clinical outcomes. Additionally, plasma exchange, calcium channel blockers, and arginine can improve laboratory values and expedite viral clearance. In the future, screening Food and Drug Administration-approved drugs and conducting multiomics analyses may lead to the discovery of new effective therapeutic options.\n                  <\/jats:p>","DOI":"10.1177\/20499361251340786","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T06:34:58Z","timestamp":1747377298000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evolving therapeutic strategies for severe fever with thrombocytopenia syndrome: from past to future"],"prefix":"10.1177","volume":"12","author":[{"given":"Yuxi","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxin","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-0593","authenticated-orcid":false,"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou City 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2008.131857"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit603"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.181463"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2608.200135"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1561"},{"key":"e_1_3_4_8_2","article-title":"A person-to-person transmission cluster of severe fever with thrombocytopenia syndrome characterized by mixed viral infections with familial and nosocomial clustering","volume":"10","author":"Wen Y","year":"2024","unstructured":"Wen Y, Fang Y, Cao F, et al. A person-to-person transmission cluster of severe fever with thrombocytopenia syndrome characterized by mixed viral infections with familial and nosocomial clustering. Heliyon 2024; 10: e24502.","journal-title":"Heliyon"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0047"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2024.107279"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1748521"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00610-1"},{"key":"e_1_3_4_13_2","first-page":"101133","article-title":"Global epidemiology of severe fever with thrombocytopenia syndrome virus in human and animals: a systematic review and meta-analysis","volume":"48","author":"Cui H","year":"2024","unstructured":"Cui H, Shen S, Chen L, et al. Global epidemiology of severe fever with thrombocytopenia syndrome virus in human and animals: a systematic review and meta-analysis. Lancet Reg Health West Pac 2024; 48: 101133.","journal-title":"Lancet Reg Health West Pac"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26518"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.03.001"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26877"},{"key":"e_1_3_4_17_2","first-page":"57","article-title":"Recommendations for nomenclature, clinical staging and typing of severe fever with thrombocytopenia syndrome","volume":"34","author":"Yuan Y","year":"2016","unstructured":"Yuan Y, Cui N, Yuan CJCJID. Recommendations for nomenclature, clinical staging and typing of severe fever with thrombocytopenia syndrome. BMC Infect Dis 2016; 34: 57\u201358.","journal-title":"BMC Infect Dis"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-00257-5"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2024.106181"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03421-z"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0214-z"},{"key":"e_1_3_4_22_2","first-page":"10","article-title":"Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome","author":"Li X-K","year":"2018","unstructured":"Li X-K, Lu Q-B, Chen W-W, et al. Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome. Sci Transl Med 2018; 10.","journal-title":"Sci Transl Med"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwad019"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1249"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00110-16"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00154-15"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0329-x"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00542-20"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110039"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05746-9"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109262"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.02.017"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129171"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00742-14"},{"key":"e_1_3_4_35_2","article-title":"Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome","volume":"9","author":"Li J","year":"2014","unstructured":"Li J, Han Y, Xing Y, et al. Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome. PLoS One 2014; 9: e91679.","journal-title":"PLoS One"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis452"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010489"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2022.106481"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05303-0"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19042271"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007434"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-1006-7"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.10.016"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5262"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12207"},{"key":"e_1_3_4_46_2","first-page":"13","article-title":"Severe fever with thrombocytopenia syndrome accompanied by invasive pulmonary aspergillosis: an autopsy case","author":"Iwao K","year":"2021","unstructured":"Iwao K, Kawaguchi T, Kimura M, et al. Severe fever with thrombocytopenia syndrome accompanied by invasive pulmonary aspergillosis: an autopsy case. Viruses 2021; 13.","journal-title":"Viruses"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e319"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.07.009"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.009"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.04.021"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2018.05.018"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz328"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","unstructured":"Cheng H-Y French CE Salam AP et al. Lack of evidence for ribavirin treatment of Lassa fever in systematic review of published and unpublished studies. Emerg Infect Dis 2022; 28: 1559\u20131568.","DOI":"10.3201\/eid2808.211787"},{"key":"e_1_3_4_54_2","article-title":"Ribavirin for treating Crimean Congo haemorrhagic fever","volume":"6","author":"Johnson S","year":"2018","unstructured":"Johnson S, Henschke N, Maayan N, et al. Ribavirin for treating Crimean Congo haemorrhagic fever. Cochrane Database Syst Rev 2018; 6: CD012713.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.08.011"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.4.704"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2017.49.1.72"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit530"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26544"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30293-7"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19163"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.04.006"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.93.027"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107512"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108121"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-019-01364-9"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00541-3"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103591"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009103"},{"key":"e_1_3_4_70_2","first-page":"139","article-title":"Update on the use of immunoglobulin in human disease: a review of evidence","author":"Perez EE","year":"2017","unstructured":"Perez EE, Orange JS, Bonilla F, et al. Update on the use of immunoglobulin in human disease: a review of evidence. J Allergy Clin Immunol 2017; 139.","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3036"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1118039"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.141928"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70017"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104807"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29647"},{"key":"e_1_3_4_77_2","first-page":"852","article-title":"[Epidemiological characteristics of severe fever with thtrombocytopenia syndrome in China, 2011-2021]","volume":"43","author":"Chen QL","year":"2022","unstructured":"Chen QL, Zhu MT, Chen N, et al. [Epidemiological characteristics of severe fever with thtrombocytopenia syndrome in China, 2011-2021]. Zhonghua Liu Xing Bing Xue Za Zhi 2022; 43: 852\u2013859.","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007242"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-04098-x"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111736"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0423"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33884-z"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-021-00918-0"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.05.018"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.744037"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.01.051"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006603"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2211.160414"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1469440918003643"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.11.004"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03664-6"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.4900.4900"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009128"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13050785"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.07.001"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.03.015"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1419015"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2023.01.022"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad418"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S478520"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.808098"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18616-z"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28712"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28059"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1209705"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00204.x"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-005-1319-7"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.15459"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103580"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0028"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.12.028"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28894"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0677-1"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.06.058"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107217"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01471-z"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30156-5"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01979-w"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01266-6"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12462"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.01.009"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.24-0062"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2023.01.014"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.932836"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.08.001"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.09.002"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06627-1"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008801"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19364"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30269-6"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.02.006"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005746"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.05.001"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.7075-21"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.4.867"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.194"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2023.2219940"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22131"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0766"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.151791"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04776-7"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01923-09"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9052-21"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01098-2"},{"key":"e_1_3_4_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.010"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13050869"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02558-z"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-024-02150-x"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-024-02285-2"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03672-w"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.053"},{"key":"e_1_3_4_153_2","first-page":"8","article-title":"Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen","author":"Xie J","year":"2023","unstructured":"Xie J, Li H, Zhang X, et al. Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen. Nat Microbiol 2023; 8.","journal-title":"Nat Microbiol"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01801-y"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361251340786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361251340786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361251340786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:01:22Z","timestamp":1777593682000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361251340786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":153,"alternative-id":["10.1177\/20499361251340786"],"URL":"https:\/\/doi.org\/10.1177\/20499361251340786","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"article-number":"20499361251340786"}}