{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:39Z","timestamp":1777880079372,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tuberculosis (TB) affects patients' quality of life due to symptoms and social stigma, especially in low-income settings like Ghana. However, data on factors influencing health-related quality of life (HRQOL) in such environments are limited. Identifying these factors is essential for improving treatment outcomes through holistic care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study determined the impact of sociodemographic and clinical factors on HRQOL at treatment initiation, and monitored changes until the end of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A cohort of 378 newly diagnosed patients with drug-susceptible TB (mean age: 45.3\u2009\u00b1\u200915.1\u2009years) was followed across eight hospitals in the Ashanti and Eastern regions of Ghana. Patients received first-line antitubercular treatment, and HRQOL was assessed at baseline, month 2, and month 6 using an interviewer-administered SF-12v2 questionnaire. Associations between HRQOL and sociodemographic or clinical factors were examined using Chi-square or Fisher\u2019s exact tests, while logistic regression was used to estimate crude and adjusted odds ratios (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At baseline, 78.8% of participants had impaired physical HRQOL, and 25.7% were at risk of depression. At treatment completion, physical HRQOL impairment remained high (59.5%), with 15.0% still at risk of depression. Only 44.7% showed clinically significant improvement in physical HRQOL, while 39.8% improved in mental HRQOL. Employment, HIV-positive status, and alcohol use were associated with poorer mental HRQOL. Extrapulmonary TB patients demonstrated better physical HRQOL at both the beginning and end of treatment but exhibited poorer mental HRQOL at treatment completion. Widowed participants improved mentally despite poorer baseline health, while married individuals had better physical HRQOL. Higher education correlated with better baseline mental health but lower odds of significant HRQOL improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Sociodemographic and clinical factors significantly influenced HRQOL in drug-susceptible TB patients after 6\u2009months of treatment. These findings underscore the importance of targeted mental health support during and after treatment to improve patient well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251343143","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T14:40:36Z","timestamp":1749393636000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Determinants of health-related quality of life in drug-susceptible tuberculosis patients in Ghana: a prospective observational study"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8643-7163","authenticated-orcid":false,"given":"Richard Delali Agbeko","family":"Djochie","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana"},{"name":"Department of Pharmacotherapeutics and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Private Mail Bag, Cape Coast, CC-191-9699, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berko Panyin","family":"Anto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Private Mail Bag, Kumasi, Ashanti 23350, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2660-2582","authenticated-orcid":false,"given":"Mercy Naa Aduele","family":"Opare-Addo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"WHO. Global TB report 2022 https:\/\/www.who.int\/publications\/i\/item\/9789240037021 (2022 accessed 1 April 2023)."},{"key":"e_1_3_4_3_2","unstructured":"World Health Organization (WHO). Global Tuberculosis Report 2024 https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-tuberculosis-report-2024 (2024 accessed 12 February 2025)."},{"key":"e_1_3_4_4_2","unstructured":"Ghana Health Service (GHS). Ghana Marks 2024 World Tuberculosis Day - Yes We Can End TB!. Accra: Ghana Health Service."},{"key":"e_1_3_4_5_2","unstructured":"WHO. Measuring Health-related quality of life (HRQoL) - EUPATI Toolbox https:\/\/toolbox.eupati.eu\/resources\/measuring-health-related-quality-of-life-hrqol\/ (2016 accessed 5 March 2025)."},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21-0494"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2022.100324"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-12-19"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0193945905278385"},{"issue":"1","key":"e_1_3_4_10_2","first-page":"23","article-title":"Quality of life among pulmonary tuberculosis patients under treatment in Eastern Taiwan","volume":"33","author":"Chung WS","year":"2014","unstructured":"Chung WS, Liz CR, Liao LY, et al. Quality of life among pulmonary tuberculosis patients under treatment in Eastern Taiwan. Taiwan J Public Health 2014; 33(1): 23\u201335.","journal-title":"Taiwan J Public Health"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2538532"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00251-2021"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000512531"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2023.04.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313750"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12056-1"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-087218"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277192"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.116232"},{"key":"e_1_3_4_21_2","volume-title":"Tuberculosis case notification and treatment outcomes","author":"Ghana Health Service (GHS)","year":"2020","unstructured":"Ghana Health Service (GHS). Tuberculosis case notification and treatment outcomes. Accra: Ghana Health Service, 2020."},{"key":"e_1_3_4_22_2","unstructured":"GSS. Population and housing census 2021 https:\/\/statsghana.gov.gh\/gssmain\/fileUpload\/pressrelease\/2021PHCGeneralReportVol3A_PopulationofRegionsandDistricts_181121.pdf (2021 accessed 18 November 2022)."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20085518"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0858-2"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151892"},{"key":"e_1_3_4_26_2","volume-title":"SF-12: How to score the SF-12 physical and mental health summary scales","author":"Ware JE","year":"1995","unstructured":"Ware JE, Konsiki M, Keller SD. SF-12: How to score the SF-12 physical and mental health summary scales. Vol 3rd. 2nd ed. Boston, MA: The Health Institute, New England Medical Center, 1995.","edition":"2"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00919"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/idr14040055"},{"issue":"3","key":"e_1_3_4_29_2","first-page":"296","article-title":"Health status of UK patients with active tuberculosis","volume":"14","author":"Kruijshaar ME","year":"2010","unstructured":"Kruijshaar ME, Lipman M, Essink-Bot ML, et al. Health status of UK patients with active tuberculosis. Int J Tuberc Lung Dis 2010; 14(3): 296\u2013302.","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002771"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020444"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.02.66"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.2478\/pneum-2019-0024"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.4314\/mmj.v30i4.12"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-32046-0_175-1"},{"issue":"71","key":"e_1_3_4_36_2","article-title":"Change in psychological parameters and quality of life among individuals with pulmonary and extrapulmonary tuberculosis following the intensive phase of therapy: a longitudinal observational study from central India","volume":"2","author":"Vaidya S","year":"2024","unstructured":"Vaidya S, Bajaj E, Khurana AK, et al. Change in psychological parameters and quality of life among individuals with pulmonary and extrapulmonary tuberculosis following the intensive phase of therapy: a longitudinal observational study from central India. Indian J Tuberculosis 2024; 2(71): S208\u2013S213.","journal-title":"Indian J Tuberculosis"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0329-x"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-696"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-020-00335-w"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108656"},{"key":"e_1_3_4_41_2","unstructured":"NHS. Drink less\u2014Better Health\u2014NHS https:\/\/www.nhs.uk\/better-health\/drink-less\/ (2002 accessed 16 January 2023)."},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156258"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131859"},{"issue":"5","key":"e_1_3_4_44_2","article-title":"Depression and HIV: a scoping review in search of neuroimmune biomarkers","volume":"5","author":"Rakshasa-Loots AM.","year":"2023","unstructured":"Rakshasa-Loots AM. Depression and HIV: a scoping review in search of neuroimmune biomarkers. Brain Commun 2023; 5(5): fcad231.","journal-title":"Brain Commun"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000423"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbac039"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10093908"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361251343143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361251343143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361251343143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:01:24Z","timestamp":1777593684000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361251343143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,8]]},"references-count":46,"alternative-id":["10.1177\/20499361251343143"],"URL":"https:\/\/doi.org\/10.1177\/20499361251343143","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,8]]},"article-number":"20499361251343143"}}