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GBS can transition from asymptomatic colonization to pathogenic bacterium which can then lead to adverse pregnancy, maternal and neonatal outcomes. While much of the literature focuses on outcomes affecting the neonate, such as early- and late-onset neonatal sepsis, GBS is also thought to be associated with specific pregnancy and fetal adverse outcomes including preterm birth, preterm premature rupture of membranes, urinary tract infection, endometritis, and maternal sepsis. The objective of this literature review is to further address the known associations of these maternal and pregnancy outcomes, review the current strategies for GBS screening and preventative strategies, and explore the current maternal GBS vaccine candidates in development that may address the limitations of current prevention strategies with intrapartum antibiotic prophylaxis.\n                  <\/jats:p>","DOI":"10.1177\/20499361251343710","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:51:21Z","timestamp":1752072681000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Understanding GBS infection in pregnancy: exploring adverse maternal and pregnancy outcomes and the prospect of a GBS vaccine"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5149-0218","authenticated-orcid":false,"given":"Monica","family":"Sosa","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-8405","authenticated-orcid":false,"given":"Linda O.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of Washington, Seattle, WA, USA"},{"name":"Department of Global Health, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-5107","authenticated-orcid":false,"given":"Alisa","family":"Kachikis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, University of Washington, 1959 NE Pacific Street, Box 356460, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"issue":"2","key":"e_1_3_4_2_2","volume":"135","author":"Prevention of group B streptococcal early-onset disease in newborns: ACOG committee opinion, number 797","year":"2020","unstructured":"Prevention of group B streptococcal early-onset disease in newborns: ACOG committee opinion, number 797. 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