{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:11:18Z","timestamp":1785845478143,"version":"3.56.0"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vietnam has one of the highest hepatitis B virus (HBV) infection rates, with approximately 8 million people affected. Although antiviral drug resistance mutations have been reported in treatment-na\u00efve patients with chronic hepatitis B, there is limited data on primary drug resistance mutations in circulating genotypes within this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to investigate primary antiviral drug resistance mutations and common HBV genotypes in treatment-na\u00efve patients with chronic hepatitis B, particularly in cases without well-characterized resistance profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed HBV genotypes and antiviral drug resistance mutations in 113 treatment-na\u00efve patients with chronic hepatitis B in the Yenphong Medical Center, Bacninh Vietnam. The reverse transcriptase (RT) region of the HBV polymerase genes was sequenced to detect mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Genotypes B, C, and G were identified in 85.0% (96\/133), 14.1% (16\/133), and 0.9% (1\/133) of treatment-na\u00efve patients with chronic hepatitis B, respectively. Mutations in the RT region associated with antiviral drug resistance were detected in 32.7% (37\/113) of patients. In addition, the most frequent resistance mutations were rtV207M (89.2%, 33\/37), followed by A194T, L180M\u2009+\u2009M204V, V173L\u2009+\u2009M204I\u2009+\u2009L80I, and A181T\u2009+\u2009V207M\u2009+\u2009A181T, each observed in 2.7% (1\/37). Notably, no significant associations were found between resistance mutations and HBV genotype, gender, age, hepatitis B e-antigen status, baseline HBV DNA levels, or level of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights the presence of primary resistance mutations in treatment-na\u00efve patients and underscores the importance of genotypic screening prior to initiating therapy. These findings may inform treatment strategies and help reduce the risk of treatment failure, liver cirrhosis, and hepatocellular carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251344784","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T01:30:10Z","timestamp":1749951010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hepatitis B virus genotypes and antiviral drug resistance mutations in treatment-na\u00efve patients with chronic hepatitis B in Bacninh, Vietnam: a cross-sectional study"],"prefix":"10.1177","volume":"12","author":[{"given":"Minh-Cong","family":"Hoang","sequence":"first","affiliation":[{"name":"Laboratory Department, Yenphong Medical Center, Bacninh, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-9826","authenticated-orcid":false,"given":"Hong-Quan","family":"Duong","sequence":"additional","affiliation":[{"name":"Laboratory Center, Hanoi University of Public Health, 1A Duc Thang, North Tu Liem, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van-Duyet","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Diagnostic, National Hospital for Tropical Diseases, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi-Thuy-Nga","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Namdinh University of Nursing, Namdinh, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van-Lang","family":"Ngo","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences, Phenikaa University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"The-Hung","family":"Dang","sequence":"additional","affiliation":[{"name":"Laboratory Center, Hanoi University of Public Health, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00124-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00197-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i9.1190"},{"key":"e_1_3_4_5_2","first-page":"100468","article-title":"Seroprevalence of Hepatitis B, C and D in Vietnam: a systematic review and meta-analysis","volume":"24","author":"Flower B","year":"2022","unstructured":"Flower B, Hong DD, Kim HVT, et al. Seroprevalence of Hepatitis B, C and D in Vietnam: a systematic review and meta-analysis. Lancet Reg Health West Pac 2022; 24: 100468.","journal-title":"Lancet Reg Health West Pac"},{"issue":"1","key":"e_1_3_4_6_2","first-page":"16","article-title":"Hepatitis B virus infection in southern Khmer people in Cau Ke district, Tra Vinh province in 2021","volume":"511","author":"Le TDT","year":"2022","unstructured":"Le TDT, Nguyen TB, Huynh TXL, et al. Hepatitis B virus infection in southern Khmer people in Cau Ke district, Tra Vinh province in 2021. Vietnam Med J 2022; 511(1): 16\u201320.","journal-title":"Vietnam Med J"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3934\/medsci.2020023"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2023.02.013"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44604-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v11.i1.57"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn014"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00877.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04151.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20974"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26383"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22841"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835ee516"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02767.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.04.010"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00462-09"},{"issue":"10","key":"e_1_3_4_22_2","first-page":"2392","article-title":"Characteristics of hepatitis B virus genotype and sub-genotype in hepatocellular cancer patients in Vietnam","volume":"12","author":"Ho PT","year":"2022","unstructured":"Ho PT, Balzanelli MG, Distratis P, et al. Characteristics of hepatitis B virus genotype and sub-genotype in hepatocellular cancer patients in Vietnam. Diagnostics (Basel) 2022; 12(10): 2392.","journal-title":"Diagnostics (Basel)"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.65"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.12.006"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00100.x"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2016.00019"},{"issue":"1","key":"e_1_3_4_27_2","first-page":"63","article-title":"Application of realtime PCR technique to determine genotype, amount of virus in blood and resistance characteristics medicine to treat hepatitis B virus in patients at Dong Thap General Hospital","volume":"9","author":"Lao DT","year":"2014","unstructured":"Lao DT, Truong KP, Mai NL, et al. Application of realtime PCR technique to determine genotype, amount of virus in blood and resistance characteristics medicine to treat hepatitis B virus in patients at Dong Thap General Hospital. Ho Chi Minh City Open University J Science 2014; 9(1): 63\u201373.","journal-title":"Ho Chi Minh City Open University J Science"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.5.1972-1974.2001"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/135965350901400504"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23608"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S135420"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2002.00304.x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22790"},{"key":"e_1_3_4_34_2","first-page":"1056","volume-title":"Hepatology","volume":"45","author":"Hoofnagle JH","year":"2007","unstructured":"Hoofnagle JH, Doo E, Liang TJ, et al. Management of hepatitis B: summary of a clinical research workshop. Hepatology 2007; 45(4): 1056\u20131075."},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.063"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01784.x"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.01.001"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05570.x"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01882.x"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2938"},{"issue":"4","key":"e_1_3_4_42_2","first-page":"484","article-title":"Resistance to adefovir in patients with chronic hepatitis B","volume":"12","author":"Ryu SH","year":"2006","unstructured":"Ryu SH, Chung YH. Resistance to adefovir in patients with chronic hepatitis B. Korean J Hepatol 2006; 12(4): 484\u2013492.","journal-title":"Korean J Hepatol"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21698"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12831"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361251344784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361251344784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361251344784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:01:27Z","timestamp":1777593687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361251344784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,14]]},"references-count":43,"alternative-id":["10.1177\/20499361251344784"],"URL":"https:\/\/doi.org\/10.1177\/20499361251344784","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,14]]},"article-number":"20499361251344784"}}