{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:45Z","timestamp":1777880085236,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["102\/IFD\/SAN\/3021\/2012-2013"],"award-info":[{"award-number":["102\/IFD\/SAN\/3021\/2012-2013"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Manipur, a north-eastern state of India, has a high incidence of intravenous drug use with an equally high prevalence of Hepatitis C virus (HCV) infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This cross-sectional study aimed to evaluate the impact of certain risk factors enhancing the susceptibility of acquiring HCV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A total of 1008 participants from various risk groups, from nine districts across the state, were enrolled. Blood samples along with demographic data were collected from the study participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>HCV RNA was isolated and nested RT-PCR was performed followed by Sanger sequencing for genotyping. Phylogenetic and phylogeographic studies were further conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the total, 493 (48.90%) samples were HCV sero-reactive. Among the sero-reactive samples, 406 (82.35%) were HCV RNA positive. In case of the subgroup PWID\u2009+\u2009HIV, sero-reactivity (82.22%) and viremia (90.54%) were observed to be exceptionally high. It was noted that HCV sero-reactivity increased four times in people living with HIV (PLHIV) who continued to inject drugs. Three HCV genotypes and eight subtypes were circulating in this study population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In PLHIV who continued to inject drugs, HCV sero-reactivity increased four-fold. About 40% of the population living with HCV belonged to genotype 6, while genotype 1 showed a noticeable decline. Phylogeographic analyses and spatiotemporal reconstructions revealed that most of the subtypes migrated from far south-east Asian countries like Thailand, Malaysia, Myanmar, and Singapore.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251351302","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T10:52:20Z","timestamp":1752403940000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of HCV genotype 6 and its new variants among intravenous drug users in Manipur, a north-eastern state of India"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-5526","authenticated-orcid":false,"given":"Raina","family":"Das","sequence":"first","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supradip","family":"Dutta","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagnik","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aritra","family":"Biswas","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreyasi","family":"Nath","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moumita","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Verma","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upasana","family":"Baskey","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-7390","authenticated-orcid":false,"given":"Shanta","family":"Dutta","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute for Research in Bacterial Infections (NIRBI), West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Provash Chandra","family":"Sadhukhan","sequence":"additional","affiliation":[{"name":"Division of Virus Laboratory, National Institute for Research in Bacterial Infections, Indian Council of Medical Research, P-33, C.I.T. 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