{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:17:28Z","timestamp":1788387448922,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Bloodstream infections (BSI) caused by carbapenemase-producing\n                      <jats:italic>Enterobacterales<\/jats:italic>\n                      (CPE) represent a significant threat to patients with acute leukemia due to their high mortality. Ceftazidime\u2013avibactam (CAZ-AVI) has emerged as a therapeutic alternative against these infections; however, its efficacy in immunocompromised patients remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the impact of ceftazidime\u2013avibactam on mortality due to BSI caused by CPE in patients with acute leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted at the Hospital Nacional Edgardo Rebagliati Martins in Lima, Peru.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included patients diagnosed with acute leukemia who developed BSI due to CPE during their hospital stays. Mortality was assessed for up to 30\u2009days after BSI onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We evaluated 41 patients with a median age of 51\u2009years; 56.1% had acute myeloid leukemia and 43.9% had acute lymphoblastic leukemia. Mortality at 30\u2009days occurred in 60.9% of patients. The most frequent type of chemotherapy administered was induction (51.2%). Empiric antibiotic therapy with meropenem was administered to 97.6% of the patients, and ceftazidime\u2013avibactam was prescribed as a targeted therapy to 48.8%. In the multivariate Cox regression model, the prescription of ceftazidime\u2013avibactam reduced the risk of death (adjusted hazard ratio, 0.29; 95% CI: 0.09\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) compared with those who received other antibiotic therapies, such as colistin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with acute leukemia who developed bloodstream infections due to CPE during hospitalization, the prescription of ceftazidime\u2013avibactam reduced 30-day mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251362955","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T14:34:47Z","timestamp":1755354887000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of ceftazidime\u2013avibactam on mortality in bloodstream infections: a cohort study in patients with acute leukemia"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-0158","authenticated-orcid":false,"given":"Cesar","family":"Copaja-Corzo","sequence":"first","affiliation":[{"name":"Unidad de investigaci\u00f3n para la generaci\u00f3n y s\u00edntesis de evidencias en salud, Universidad San Ignacio de Loyola, Lima, Per\u00fa"},{"name":"Servicio de Infectolog\u00eda, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susy","family":"Baz\u00e1n-Ruiz","sequence":"additional","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Lima, Per\u00fa Servicio de Hematolog\u00eda, Hospital Nacional Edgardo Rebagliati Mart\u00edns, EsSalud, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Fuentes-Yufra","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Pizarro-Perea","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Nacional Edgardo Rebagliati Mart\u00edns, EsSalud, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Montiel-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"P\u00e9rez-Lazo","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda. Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2025.03.003"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024014291"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100855"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10030322"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac049"},{"key":"e_1_3_5_7_2","article-title":"How to manage KPC infections","volume":"7","author":"Bassetti M","year":"2020","unstructured":"Bassetti M, Peghin M. How to manage KPC infections. 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Perfil de la poblaci\u00f3n asegurada de EsSalud I trimestre 2023 https:\/\/repositorio.essalud.gob.pe\/handle\/20.500.12959\/4201 (2023 accessed 27 March 2025)."},{"key":"e_1_3_5_22_2","first-page":"225","article-title":"Trasplante de c\u00e9lulas madre hematopoy\u00e9ticas en el Per\u00fa: experiencia y desaf\u00edos del centro de trasplante m\u00e1s grande del Per\u00fa","author":"Aranda-Gomero L","year":"2022","unstructured":"Aranda-Gomero L, Pichardo-Rodriguez R, Fernandez-Vert\u00edz I, et al. Trasplante de c\u00e9lulas madre hematopoy\u00e9ticas en el Per\u00fa: experiencia y desaf\u00edos del centro de trasplante m\u00e1s grande del Per\u00fa. Rev Fac Med Hum 2022; 22(2): 225\u2013227.","journal-title":"Rev Fac Med Hum"},{"key":"e_1_3_5_23_2","unstructured":"EsSalud. 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