{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:34:50Z","timestamp":1777880090263,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Fascioliasis, caused by\n                      <jats:italic>Fasciola hepatica<\/jats:italic>\n                      and\n                      <jats:italic>F. gigantica<\/jats:italic>\n                      , is a neglected tropical disease that has significant medical and veterinary importance. This foodborne zoonotic trematodiases primarily affects poor rural populations in tropical and subtropical areas, where prevalence can be as high as 21%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aims to characterize the clinical features, laboratory findings, and outcomes of fascioliasis in a real-world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients\u2009\u2a7e\u200918\u2009years old diagnosed with fascioliasis were identified from TriNetX, a global federated research network, on October 26, 2024. We used the International Classification of Diseases results to define fascioliasis (ICD-10 code B66.3) for the period 2021\u20132024. These data include demographics, diagnoses, comorbidities, procedures, clinical laboratory results, and medications. All variables except outcomes were not time-bound to the diagnosis date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In a cohort of 174 predominantly middle-aged, female, and Caucasian patients, we found high rates of essential hypertension, neoplasms, heart disease, liver disease, and sleep disorders. Key symptoms included upper abdominal pain, skin complaints, dyspnea, and malaise\/fatigue. Some outcomes were hepatomegaly, cholelithiasis, and cholangitis in 10% of patients, with hepatic cirrhosis being rare. Among hospitalized patients within 3\u2009months of diagnosis, 63% experienced abdominal pain. Of the 13 patients who developed cholangitis or cholelithiasis, most were men, had abdominal pain, nausea\/vomiting, dysphagia, and ascites with a history of liver or intrahepatic bile neoplasia. A total of 90-day mortality was low (less than 6%). Triclabendazole was reported in only 6% of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In a large real-world case series of fascioliasis, we found a high frequency of comorbidities and typical gastrointestinal symptoms. The low use of triclabendazole may be due to limited access to the product in certain countries or its omission from the database if prescribed in the outpatient setting. Mortality was very low, but biliary and liver complications warrant characterization through additional prospective clinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361251365508","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T08:41:12Z","timestamp":1757148072000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of the clinical features, laboratory findings, and outcomes of human fascioliasis in a global network: a retrospective mutlicenter study"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-8652","authenticated-orcid":false,"given":"Andr\u00e9s F.","family":"Henao-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Celis-Salinas","sequence":"additional","affiliation":[{"name":"Universidad Nacional de la Amazon\u00eda Peruana (UNAP), Iquitos, Per\u00fa"},{"name":"Department of Infectious and Tropical Diseases, Hospital Regional de Loreto \u201cFelipe Santiago Arriola Iglesias,\u201d Iquitos, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Casapia-Morales","sequence":"additional","affiliation":[{"name":"Universidad Nacional de la Amazon\u00eda Peruana (UNAP), Iquitos, Per\u00fa"},{"name":"Department of Infectious and Tropical Diseases, Hospital Regional de Loreto \u201cFelipe Santiago Arriola Iglesias,\u201d Iquitos, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-0839","authenticated-orcid":false,"given":"Edgar A.","family":"Ramirez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Universidad Nacional de la Amazon\u00eda Peruana (UNAP), Iquitos, Per\u00fa"},{"name":"Department of Infectious and Tropical Diseases, Hospital Regional de Loreto \u201cFelipe Santiago Arriola Iglesias,\u201d Iquitos, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-0195","authenticated-orcid":false,"given":"Daniel B.","family":"Chastain","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy, UGA College of Pharmacy, SWGA Clinical Campus, Albany, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-6170","authenticated-orcid":false,"given":"Alicia","family":"Hidron","sequence":"additional","affiliation":[{"name":"Programa de Enfermedades Infecciosas, Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medell\u00edn, Colombia"},{"name":"Secci\u00f3n de Enfermedades Infecciosas, Hospital Pablo Tob\u00f3n Uribe, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Franco-Paredes","sequence":"additional","affiliation":[{"name":"Hospital Infantil de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico City, M\u00e9xico"},{"name":"Instituto Conmemorativo Gorgas de Estudios de la Salud, Panam\u00e1 City, Panam\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-6280","authenticated-orcid":false,"given":"Nelson Iv\u00e1n","family":"Agudelo Higuita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"},{"name":"Instituto de Enfermedades Infecciosas y Parasitolog\u00eda Antonio Vidal, Tegucigalpa, Honduras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-0432","authenticated-orcid":false,"given":"Luis A.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, and Department of Microbiology and Immunology, Stony Brook University, 101 Nicolls Rd, HSC16-027 J, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04223"},{"key":"e_1_3_4_3_2","article-title":"The global prevalence of human fascioliasis: a systematic review and meta-analysis","volume":"10","author":"Rosas-Hostos Infantes LR","year":"2023","unstructured":"Rosas-Hostos Infantes LR, Paredes Yataco GA, Ortiz-Mart\u00ednez Y, et al. 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