{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:35:04Z","timestamp":1777880104323,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Babesiosis and Lyme disease are tick-borne infections endemic to the northeastern and upper Midwestern United States. Although both diseases can involve multiple organ systems, acute liver failure (ALF) is exceedingly uncommon. Co-infection with\n                    <jats:italic toggle=\"yes\">Babesia microti<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Borrelia burgdorferi<\/jats:italic>\n                    may exacerbate disease severity, create diagnostic uncertainty, and delay appropriate therapy. We describe a 77-year-old man with type II diabetes mellitus, stage IV chronic kidney disease, and heart failure with preserved ejection fraction who presented with dyspnea, cough, and peripheral edema. Initial evaluation suggested decompensated heart failure and acute kidney injury consistent with cardiorenal syndrome. Within 24\u2009h, however, he developed ALF (total bilirubin 6.8\u2009mg\/dL; aspartate aminotransferase 2656\u2009U\/L; alanine aminotransferase 1421\u2009U\/L; INR 3.5), thrombocytopenia (95\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L), acute anemia (hemoglobin 7.7\u2009g\/dL), and encephalopathy. Initial infectious, autoimmune, and ischemic evaluations were unrevealing. Despite empiric antimicrobial therapy with intravenous ceftriaxone, vancomycin, and doxycycline, his condition rapidly deteriorated, and he died. Postmortem testing identified\n                    <jats:italic toggle=\"yes\">B. microti<\/jats:italic>\n                    parasitemia of 2.4% and\n                    <jats:italic toggle=\"yes\">B. burgdorferi<\/jats:italic>\n                    co-infection. This case highlights the importance of considering tick-borne coinfections in patients presenting with ALF and shock, even in the absence of classic features such as fever, rash, or overt hemolysis. Increased clinician awareness of atypical presentations of endemic tick-borne diseases may help reduce diagnostic delays and improve outcomes in severe or unusual clinical scenarios.\n                  <\/jats:p>","DOI":"10.1177\/20499361261416190","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:13:15Z","timestamp":1769314395000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A lethal combination: fulminant liver failure due to\n                    <i>Babesia microti<\/i>\n                    and\n                    <i>Borrelia burgdorferi<\/i>\n                    co-infection"],"prefix":"10.1177","volume":"13","author":[{"given":"Aya","family":"Elalfy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5187-421X","authenticated-orcid":false,"given":"Danilo","family":"Grahovac","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Mayo Clinic, La Crosse, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-8812","authenticated-orcid":false,"given":"Igor","family":"Dumic","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Mayo Clinic, Eau Claire, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4531-277X","authenticated-orcid":false,"given":"Tatjana","family":"Gavrancic","sequence":"additional","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2022.02.009"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.376"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6934149"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.121"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5719081"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24495"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530450047031"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab050"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-06"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2018.06.006"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01596"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15328"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002340"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0146"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-017-0179-z"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000485373"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201610001-01825"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae504"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0267"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370105"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/CLD.0000000000000025"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-022-00506-6"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/525852"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac525"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2504.180202"}],"container-title":["Therapeutic 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