{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:07:12Z","timestamp":1779188832271,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite prophylactic pharmacotherapy being ranked as the best intervention yet, poor treatment adherence tempers tuberculosis preventive therapy (TPT) efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to investigate TPT non-adherence among household contacts and its determinants following the rollout of the 3HP regimen in northwest Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A facility-based multicenter retrospective study was conducted in selected hospitals of northwest Ethiopia from October 17 to February 21, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Target populations were TPT-eligible household contacts (\u2a7d15\u2009years old) based on the national tuberculosis treatment guideline. Univariate and multivariate binary logistic regression model was fitted to identify potential predictors.\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -Value\u2009&lt;\u20090.05 was employed to adjudicate the significance level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 494 household contacts (HHCs) enrolled in this study, 27.94% were non-adherent. Age (5\u201310\u2009years: adjusted odds ratio (AOR) (95% CI): 1.92 (1.05\u20133.19); 10\u201315\u2009years: AOR (95% CI): 2.04 (1.01\u20134.12)), parental status (AOR (95% CI): 1.87 (1.02\u20135.24)), comorbidity (AOR (95% CI): 2.92 (1.08\u20135.69)), poor nutritional status (AOR (95% CI): 1.30 (1.06\u20132.43)), adverse drug reactions (AOR (95% CI): 4.01 (1.03\u20138.20)), adherence support (AOR (95% CI): 1.56 (1.08\u20136.69)) and TPT regimen type (AOR (95% CI): 4.23 (1.85\u20136.53)) predicts non-adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Altogether, this study revealed a high level of non-adherence among HHCs in northwest Ethiopia, falling short of the national 2025\/26 TPT targets. TPT should be accompanied by firm counseling and routine supervision to improve adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361261426969","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:53:56Z","timestamp":1773251636000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-adherence and its predictors among pediatric household contacts on tuberculosis preventive therapy in the 3HP era: A multicenter observational study"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-4014","authenticated-orcid":false,"given":"Woretaw Sisay","family":"Zewdu","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muluken Adela","family":"Alemu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8792","authenticated-orcid":false,"given":"Tilaye Arega","family":"Moges","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2945-0306","authenticated-orcid":false,"given":"Sisay Sitotaw","family":"Anberbr","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Birhan University, Debre Birhan, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9361-1033","authenticated-orcid":false,"given":"Desalegn Addis","family":"Mussie","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3431-8187","authenticated-orcid":false,"given":"Abel Temeche","family":"Kassaw","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demewoz","family":"Kefale","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7567-5614","authenticated-orcid":false,"given":"Tigabu Eskeziya","family":"Zerihun","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3309-9102","authenticated-orcid":false,"given":"Fisseha Nigussie","family":"Dagnew","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-4551","authenticated-orcid":false,"given":"Samuel Berihun","family":"Dagnew","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Pharmacy Education and Clinical Services Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Silent epidemic: A call to action against child tuberculosis","author":"International Union Against Tuberculosis and Lung Disease (The Union)","year":"2025","unstructured":"International Union Against Tuberculosis and Lung Disease (The Union). 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