{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:03:00Z","timestamp":1785009780610,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    We present the case of a 9-year-old girl from the Peruvian Andean Region (Ancash), diagnosed with fascioliasis, who was also suffering from severe malnutrition. Initially, she was referred for treatment of skin necrosis caused by cutaneous visceral loxoscelism, but during hospitalisation she developed persistent vomiting and pancreatitis. Magnetic resonance cholangiography showed dilation of the intrahepatic and common bile ducts. Endoscopic retrograde cholangiopancreatography identified an adult\n                    <jats:italic toggle=\"yes\">Fasciola<\/jats:italic>\n                    spp. specimen. She also expelled adult worms of\n                    <jats:italic toggle=\"yes\">Ascaris lumbricoides<\/jats:italic>\n                    during vomiting. Delivery of triclabendazole was initiated via a nasogastric tube initially and subsequently via the rectal route, although absorption was limited due to persistent oral intolerance. The patient later developed upper gastrointestinal bleeding and sepsis of abdominal origin and died. During this period, the patient remained on broad-spectrum antibiotic therapy, although sepsis was attributed to persistent biliary obstruction. Fascioliasis and ascariasis should remain in the differential diagnosis for pancreatitis and cholestasis in paediatric patients from endemic areas. Oral triclabendazole is the treatment of choice for fascioliasis, but surgical management should be considered in cases of persistent biliary obstruction or treatment failure, usually seen in complicated chronic infections.\n                  <\/jats:p>","DOI":"10.1177\/20499361261430150","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:33:58Z","timestamp":1784784838000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic\n                    <i>Fasciola hepatica<\/i>\n                    infection in a patient with cutaneous visceral loxoscelism: paediatric case report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-5376","authenticated-orcid":false,"given":"Blanca","family":"Salazar-Mesones","sequence":"first","affiliation":[{"name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0931-1182","authenticated-orcid":false,"given":"Laura Melissa","family":"Mori-Llontop","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0687-3112","authenticated-orcid":false,"given":"Alfredo","family":"Chiappe-Gonzalez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias Biom\u00e9dicas, Universidad Ricardo Palma, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lazarte-Rantes","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaila","family":"Contreras-Alvitez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Pe\u00f1aloza-Ore","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Stony Brook University, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-7284","authenticated-orcid":false,"given":"Jos\u00e9 W.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud del Ni\u00f1o-San Borja"},{"name":"Universidad Cient\u00edfica del Sur, Lima, Per\u00fa. Panamericana Sur Km 19, Villa El Salvador, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"149","article-title":"Human fascioliasis: current epidemiological status and strategies for diagnosis, treatment, and control","volume":"11","author":"Caravedo MA","year":"2020","unstructured":"Caravedo MA, Cabada MM. Human fascioliasis: current epidemiological status and strategies for diagnosis, treatment, and control. Res Rep Trop Med 2020; 11: 149\u2013158.","journal-title":"Res Rep Trop Med"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2022.109766"},{"key":"e_1_3_4_4_2","unstructured":"Centers for Disease Control and Prevention. (2024 February 14). Fasciola (liver flukes). https:\/\/www.cdc.gov\/liver-flukes\/fasciola\/"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.52787\/WERX8637"},{"key":"e_1_3_4_6_2","article-title":"The global prevalence of human fascioliasis: a systematic review and meta-analysis","volume":"10","author":"Rosas-Hostos Infantes LR","year":"2023","unstructured":"Rosas-Hostos Infantes LR, Paredes Yataco GA, Ortiz-Mart\u00ednez Y, et al. The global prevalence of human fascioliasis: a systematic review and meta-analysis. Ther Adv Infect Dis 2023; 10: 20499361231185413.","journal-title":"Ther Adv Infect Dis"},{"issue":"4","key":"e_1_3_4_7_2","first-page":"389","article-title":"Fasciola hepatica infection in Peru: an emerging disease","volume":"27","author":"Marcos LA","year":"2007","unstructured":"Marcos LA, Terashima A, Leguia G. Fasciola hepatica infection in Peru: an emerging disease. Rev Gastroenterol Peru 2007; 27(4): 389\u2013396.","journal-title":"Rev Gastroenterol Peru"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0988"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.008"},{"issue":"2","key":"e_1_3_4_10_2","first-page":"148","article-title":"Hepatic fascioliasis: a diagnostic challenge?","volume":"21","author":"Jim\u00e9nez J","year":"2001","unstructured":"Jim\u00e9nez J, Loja D, Ruiz E, Maco V, et al. Hepatic fascioliasis: a diagnostic challenge? Rev Gastroenterol Peru 2001; 21(2): 148\u2013152.","journal-title":"Rev Gastroenterol Peru"},{"issue":"3","key":"e_1_3_4_11_2","first-page":"228","article-title":"Clinical characteristics of chronic Fasciola hepatica infection in children","volume":"22","author":"Marcos LA","year":"2002","unstructured":"Marcos LA, Maco V, Terashima MA, et al. Clinical characteristics of chronic Fasciola hepatica infection in children. Rev Gastroenterol Peru 2002; 22(3): 228\u2013233.","journal-title":"Rev Gastroenterol Peru"},{"issue":"2","key":"e_1_3_4_12_2","first-page":"143","article-title":"Human fascioliasis and gastrointestinal involvement: study of 277 patients at the National Hospital Cayetano Heredia. 1970-2002","volume":"24","author":"Blancas G","year":"2004","unstructured":"Blancas G, Terashima A, Magui\u00f1a C, et al. Human fascioliasis and gastrointestinal involvement: study of 277 patients at the National Hospital Cayetano Heredia. 1970-2002. Rev Gastroenterol Peru 2004; 24(2): 143\u2013157.","journal-title":"Rev Gastroenterol Peru"},{"key":"e_1_3_4_13_2","first-page":"4104","article-title":"Distomatosis caused by Fasciola hepatica. A report on 8 cases","volume":"176","author":"Ayewsa Dean C","year":"1985","unstructured":"Ayewsa Dean C, Mu\u00f1oz Fern\u00e1ndez J, Ague Aparicio J, et al. Distomatosis caused by Fasciola hepatica. A report on 8 cases. Rev Clin Esp 1985; 176: 4104.","journal-title":"Rev Clin Esp"},{"issue":"6","key":"e_1_3_4_14_2","first-page":"888","article-title":"Fasciola hepatica: as fever of unknown origin without eosinophilia","author":"Paulino Basulto M","year":"2002","unstructured":"Paulino Basulto M, Pila P\u00e9rez R, Pila Pel\u00e1ez R, et al. Fasciola hepatica: as fever of unknown origin without eosinophilia. Arch Med Camag\u00fcey 2002; 6(Suppl. 2): 888\u2013894.","journal-title":"Arch Med Camag\u00fcey"},{"issue":"3","key":"e_1_3_4_15_2","first-page":"7","article-title":"Comparaci\u00f3n de las t\u00e9cnicas Kato-Katz, TSET y TSR en el diagn\u00f3stico de infecci\u00f3n por Fasciola hep\u00e1tica en humanos. Revista de la Universidad Industrial de Santander","volume":"44","author":"Uribe Delgado NU","year":"2012","unstructured":"Uribe Delgado NU, Sierra Balc\u00e1rcel RF, Espinosa C. Comparaci\u00f3n de las t\u00e9cnicas Kato-Katz, TSET y TSR en el diagn\u00f3stico de infecci\u00f3n por Fasciola hep\u00e1tica en humanos. Revista de la Universidad Industrial de Santander. Salud UIS 2012; 44(3): 7\u201312.","journal-title":"Salud UIS"},{"issue":"1","key":"e_1_3_4_16_2","first-page":"75","article-title":"Endoscopic extraction of live Fasciola hepatica by ERCP: report of two cases and literature review","volume":"33","author":"Lazo Molina L","year":"2013","unstructured":"Lazo Molina L, Garrido Acedo R, C\u00e1rdenas Ram\u00edrez B, et al. Endoscopic extraction of live Fasciola hepatica by ERCP: report of two cases and literature review. Rev Gastroenterol Peru 2013; 33(1): 75\u201381.","journal-title":"Rev Gastroenterol Peru"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.01.001"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106762"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.10.009"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2707.203900"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261430150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361261430150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261430150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:48:12Z","timestamp":1785008892000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361261430150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":19,"alternative-id":["10.1177\/20499361261430150"],"URL":"https:\/\/doi.org\/10.1177\/20499361261430150","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"20499361261430150"}}