{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:06:45Z","timestamp":1779696405985,"version":"3.53.1"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 82300089"],"award-info":[{"award-number":["Grant No. 82300089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"china postdoctoral science foundation","doi-asserted-by":"publisher","award":["2023M742179"],"award-info":[{"award-number":["2023M742179"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014892","name":"aerospace center hospital","doi-asserted-by":"publisher","award":["YN202417"],"award-info":[{"award-number":["YN202417"]}],"id":[{"id":"10.13039\/501100014892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    This case report illustrates a diagnostic and therapeutic challenge in a highly immunocompromised host: severe pneumonia occurring late after autologous hematopoietic stem cell transplantation (auto-HSCT). A 57-year-old male with angioimmunoblastic T-cell lymphoma (AITL) presented with hypoxemic respiratory failure 1\u2009year post-auto-HSCT, a timeline extending beyond the typical high-risk period for opportunistic infections. A profoundly low CD4+ T-cell count (172\/\u00b5L) was identified as the key predisposing factor. Metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) enabled rapid, unbiased pathogen detection, confirming cytomegalovirus (CMV) pneumonia (viral load: 3.0\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    copies\/mL) with\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    coinfection. An integrated management strategy was instituted, comprising early empiric coverage for\n                    <jats:italic toggle=\"yes\">Pneumocystis jirovecii<\/jats:italic>\n                    pneumonia, targeted therapy with ganciclovir and levofloxacin, and adjunctive immunomodulation using intravenous immunoglobulin and corticosteroids. This comprehensive approach resulted in full recovery, highlighting that the severity of immune suppression\u2014rather than time since transplantation alone\u2014determines infection risk. This case challenges the conventional time-based risk paradigm and supports immune-guided surveillance. It underscores the transformative role of mNGS in diagnosing complex infections in immunocompromised patients and advocates for a management paradigm that concurrently addresses pathogen eradication and host immune dysfunction.\n                  <\/jats:p>","DOI":"10.1177\/20499361261450721","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:33:17Z","timestamp":1779445997000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Late-onset cytomegalovirus pneumonia after autologous stem cell transplantation for angioimmunoblastic T-cell lymphoma: a case report"],"prefix":"10.1177","volume":"13","author":[{"given":"Zhe","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5446-9656","authenticated-orcid":false,"given":"Wailong","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital 15 Yuquan Road, Haidian District, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13184"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000841"},{"key":"e_1_3_4_4_2","first-page":"1","article-title":"Successful treatment of ceftazidime\/avibactam combined with aztreonam in the NDM-producing Klebsiella pneumoniae bloodstream and intestinal infections in a NK\/T lymphoma patient with agranulocytosis during autologous hematopoietic stem cell transplantation: a case report","author":"Liu S","year":"2022","unstructured":"Liu S, Lin Q, Ouyang L, et al. Successful treatment of ceftazidime\/avibactam combined with aztreonam in the NDM-producing Klebsiella pneumoniae bloodstream and intestinal infections in a NK\/T lymphoma patient with agranulocytosis during autologous hematopoietic stem cell transplantation: a case report. Eur J Clin Microbiol Infect Dis 2022; 1\u20134.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2161510"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2453"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00582-z"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15371"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae321"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05029-4"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-22-1216"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf390"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.07.029"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106860"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-023-00663-2"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261450721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361261450721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261450721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:46:42Z","timestamp":1779695202000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361261450721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":16,"alternative-id":["10.1177\/20499361261450721"],"URL":"https:\/\/doi.org\/10.1177\/20499361261450721","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"20499361261450721"}}