{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:03:17Z","timestamp":1779696197955,"version":"3.53.1"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While the need for complete device removal is well-established for cardiovascular implantable electronic device (CIED) infections, there is insufficient evidence on the optimal duration of antimicrobial therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To examine how antimicrobial duration affects clinical outcomes of patients presenting with CIED-associated bacteremia and lead endocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective cohort study conducted at a quaternary care hospital in Houston, TX, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients who underwent device removal for a primary indication of bacteremia or lead endocarditis over a 10-year period were stratified by prescribed duration of antibiotics as \u2a7d2\u2009weeks or &gt;2\u2009weeks post-extraction. Measured outcomes included all-cause mortality at 90\u2009days, recurrent bacteremia, infectious complications, and hospital length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 747 patients who underwent lead extraction at Baylor St. Luke\u2019s Medical Center between June 2013 and December 2023, 79 cases met the inclusion criteria. Baseline characteristics were similar between cohorts. Mean duration of antibiotics prescription was 12.6 versus 38.6\u2009days. There was no observed difference in survival (HR 0.693, 95% CI 0.085\u20135.652,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.438), recurrent bacteremia (7% vs 6%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.952), infectious complications (27% vs 30%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.817), and hospital length of stay (mean 9.9 vs 13.3,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.360) between the \u2a7d2\u2009weeks and &gt;2\u2009weeks cohort, respectively. Five patients had recurrence, all of whom had bacteremia from\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">Serratia<\/jats:italic>\n                      sp. and an underlying left ventricular assist device or valve replacement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Shorter duration of antibiotics after complete CIED removal had similar rates of mortality or recurrent bacteremia. Recurrence was associated with bacteremia from high-risk organisms with potential for secondary seeding of other cardiovascular prostheses. Larger prospective studies are needed to explore these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20499361261451368","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:05:42Z","timestamp":1779455142000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Duration of antimicrobial therapy in cardiovascular implantable electronic device associated systemic infections: a retrospective analysis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-6764","authenticated-orcid":false,"given":"Emily Y.","family":"Xiao","sequence":"first","affiliation":[{"name":"Baylor College of Medicine Department of Internal Medicine 7200 Cambridge Street, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Temple University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-7187","authenticated-orcid":false,"given":"Sarwat","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick A.","family":"Draeger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiz M.","family":"Baqai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-1604","authenticated-orcid":false,"given":"Mihail G.","family":"Chelu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX, USA"},{"name":"Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Heart Institute at Baylor College of Medicine and Baylor St. Luke\u2019s Medical Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-0526","authenticated-orcid":false,"given":"M. Rizwan","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx080"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12518"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192665"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001187"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01683-17"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.09.001"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-1222-TIBCCA"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz246"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx132"}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261451368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361261451368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261451368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:16:15Z","timestamp":1779693375000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361261451368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":10,"alternative-id":["10.1177\/20499361261451368"],"URL":"https:\/\/doi.org\/10.1177\/20499361261451368","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"20499361261451368"}}