{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:04:46Z","timestamp":1784988286647,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Infection"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Magnusiomyces clavatus<\/jats:italic>\n                    , formerly\n                    <jats:italic toggle=\"yes\">Saprochaete clavata<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">Geotrichum clavatum<\/jats:italic>\n                    , is an ascomycetous yeast found in the environment as well as the gastrointestinal and respiratory tracts of humans. It has been described as an emerging, albeit rare, cause of invasive fungal disease affecting immunocompromised patients. Intrinsic resistance to fluconazole and echinocandins has been theorized; however, little else is known regarding optimal treatment regimens for this opportunistic pathogen. To our knowledge, only 13 infectious cases have been described in pediatric patients, all of which utilized a combination of antifungals including liposomal amphotericin B (LAmB) and voriconazole with or without flucytosine (5-FC). Here we report a case of a 4-year-old, 12.3\u2009kg, female patient who immigrated from Ukraine and was admitted to our institution for an allogeneic umbilical cord blood transplant in the setting of bone marrow failure secondary to Fanconi anemia. On day +6 after cell transplantation, the patient developed febrile neutropenia found to be because of invasive\n                    <jats:italic toggle=\"yes\">M. clavatus<\/jats:italic>\n                    fungemia on day +7. The patient was empirically treated with LAmB, micafungin, and posaconazole (POS), the latter of which failed to reach therapeutic levels. Ultimately, our patient defervesced and cleared blood cultures after transitioning LAmB to 5-FC, followed by definitive treatment with isavuconazole (ISA) monotherapy. To our knowledge, this is the first case of pediatric\n                    <jats:italic toggle=\"yes\">M. clavatus<\/jats:italic>\n                    ultimately treated with 5-FC plus POS followed by ISA alone.\n                  <\/jats:p>","DOI":"10.1177\/20499361261457479","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:36:22Z","timestamp":1784784982000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Magnusiomyces clavatus<\/i>\n                    fungemia treated with combination antifungals including isavuconazole in an immunocompromised pediatric patient: a case report"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8944-028X","authenticated-orcid":false,"given":"Amanda Z.","family":"McPherson","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Children\u2019s Hospital Colorado, University of Colorado Health Science Center, Denver, CO, USA"},{"name":"Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, 1120 15th Street, Augusta, GA, USA"},{"name":"Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Children\u2019s Hospital Colorado, University of Colorado Health Science Center, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacie","family":"Rytlewski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Health Science Center, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Bacon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Health Science Center, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira E.","family":"Frappa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Children\u2019s Hospital Colorado, University of Colorado Health Science Center, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02196"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01834-21"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02615-20"},{"key":"e_1_3_4_5_2","first-page":"81","article-title":"Geotrichum clavatum an emerging pathogen responsible for invasive infection in two neutropenic leukemia patients","volume":"19","author":"Lacroix C","year":"2007","unstructured":"Lacroix C, Brethon B, Boissel N, et al. Geotrichum clavatum an emerging pathogen responsible for invasive infection in two neutropenic leukemia patients. J Chemother 2007; 19: 81.","journal-title":"J Chemother"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw044"},{"key":"e_1_3_4_7_2","first-page":"130","article-title":"Invasive fungal infection caused by Geotrichum clavatum in an acute leukemia child: first documented case from mainland China","volume":"72","author":"Liu X","year":"2018","unstructured":"Liu X, Zhou W, Jiang Y, et al. Invasive fungal infection caused by Geotrichum clavatum in an acute leukemia child: first documented case from mainland China. J Infect Dis 2018; 72: 130\u2013132.","journal-title":"J Infect Dis"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2018.12.005"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13963"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00084"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2022.2070502"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202365012"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30297"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002686"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2023.116148"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2850"},{"issue":"4","key":"e_1_3_4_17_2","first-page":"400","article-title":"18S rRNA sequencing and homology analysis of post-traumatic bloodstream infection with Saprochaete clavata (Magnusiomyces clavatus) and a case report","volume":"46","author":"Jia W","year":"2024","unstructured":"Jia W, Chen G, Li W, et al. 18S rRNA sequencing and homology analysis of post-traumatic bloodstream infection with Saprochaete clavata (Magnusiomyces clavatus) and a case report. New Microbiol 2024; 46(4): 400\u2013406.","journal-title":"New Microbiol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01607-21"},{"key":"e_1_3_4_19_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Interpretation of MICs for rare yeast without breakpoints in breakpoint tables version 2 2024."},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.02.007"},{"issue":"2","key":"e_1_3_4_21_2","first-page":"1034","article-title":"Geotrichum clavatum infection in the hematological patient undergoing allogenic transplant: case report","volume":"2","author":"Rinaldi A","year":"2022","unstructured":"Rinaldi A, Prezioso L, Cambo B, et al. Geotrichum clavatum infection in the hematological patient undergoing allogenic transplant: case report. J Clin Med Surgery 2022; 2(2): 1034.","journal-title":"J Clin Med Surgery"},{"key":"e_1_3_4_22_2","unstructured":"Isavuconazonium Sulfate. In: Lexi-Drugs. UpToDate Inc http:\/\/online.lexi.com (2024 accessed 1 May 2026)."},{"key":"e_1_3_4_23_2","unstructured":"Voriconazole. In: Lexi-Drugs. UpToDate Inc http:\/\/online.lexi.com (2024 accessed 1 May 2026)."}],"container-title":["Therapeutic Advances in Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261457479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20499361261457479","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20499361261457479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:55:28Z","timestamp":1784987728000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20499361261457479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"alternative-id":["10.1177\/20499361261457479"],"URL":"https:\/\/doi.org\/10.1177\/20499361261457479","relation":{},"ISSN":["2049-9361","2049-937X"],"issn-type":[{"value":"2049-9361","type":"print"},{"value":"2049-937X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"20499361261457479"}}