{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:41:17Z","timestamp":1777880477471,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The initiation of oral anticoagulation therapy after valve replacement surgery requires strict monitoring because these patients are at high risk for the development of thrombotic complications and present an increased risk of bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study was to examine the total healthcare costs of oral anticoagulant treatment with vitamin K antagonists in patients with metallic prosthetic valves in the mitral position.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from clinical records were used in the study including international normalized ratio results, number of medical visits, type of anticoagulant, use of rescue medication and hospital admissions from related complications. The drug cost was calculated based on the official Spanish Ministry of Health price list. Monitoring expenses were included in the cost of the medical supplies used in the procedures. Hospitalization costs were calculated using the diagnosis-related group price for each case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We collected data from 151 patients receiving oral anticoagulation therapy with vitamin K antagonist who were diagnosed with mitral prosthesis (n\u2009=\u200990), mitro-aortic prosthesis (n\u2009=\u200957), and mitral and tricuspid prosthesis (n\u2009=\u20094). The total direct healthcare cost was \u20ac15302.59, with a mean total cost per patient per year of \u20ac1558.15 (\u00b12774.58) consisting of 44.38 (\u00b142.30) for drug cost, \u20ac71.41 (\u00b121.43) for international normalized ratio monitoring, \u20ac429.52 (\u00b1126.87) for medical visits, \u20ac26.31 (\u00b128.38) for rescue medication and \u20ac986.53 (\u00b12735.68) for related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Most direct healthcare costs associated with the sampled patients arose from the specialist-care monitoring required for treatment. Good monitoring is inversely related to direct healthcare costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050312116663123","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T22:03:20Z","timestamp":1470693800000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cost of vitamin K antagonist anticoagulant treatment in patients with metallic prosthetic valve in mitral position"],"prefix":"10.1177","volume":"4","author":[{"given":"Gabriela","family":"Ene","sequence":"first","affiliation":[{"name":"Departamento de Hematolog\u00eda, Instituto de Investigaci\u00f3n sanitaria, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Avenida de los Reyes Cat\u00f3licos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ar\u00e1nzazu","family":"Garcia Raso","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda, Instituto de Investigaci\u00f3n sanitaria, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Avenida de los Reyes Cat\u00f3licos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almudena","family":"Gonzalez-Dominguez Weber","sequence":"additional","affiliation":[{"name":"Econom\u00eda y Salud, Max Weber Institute, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Hidalgo-Vega","sequence":"additional","affiliation":[{"name":"Department of Economic and Financial Analysis, Faculty of Legal and Social Sciences, University of Castilla-La Mancha, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Llamas","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda, Instituto de Investigaci\u00f3n sanitaria, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Avenida de los Reyes Cat\u00f3licos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"bibr1-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2305"},{"key":"bibr2-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"bibr3-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907013410101"},{"key":"bibr4-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079169.15862.13"},{"key":"bibr5-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"bibr6-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"bibr7-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00463-4"},{"issue":"5","key":"bibr8-2050312116663123","first-page":"e84","volume":"114","author":"American College of Cardiology\/American Heart Association Task Force on Practice Guidelines; Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions. 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Available at: https:\/\/www.bocm.es\/"},{"issue":"3","key":"bibr16-2050312116663123","first-page":"525","volume":"6","author":"Navarro JL","year":"2008","journal-title":"Rev Adm Sanit"},{"key":"bibr17-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-46"},{"key":"bibr18-2050312116663123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.03.011"}],"container-title":["SAGE Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050312116663123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050312116663123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050312116663123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:12:46Z","timestamp":1777594366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050312116663123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":18,"alternative-id":["10.1177\/2050312116663123"],"URL":"https:\/\/doi.org\/10.1177\/2050312116663123","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,1]]},"article-number":"2050312116663123"}}