{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:03:26Z","timestamp":1782817406608,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the clinical utility of tumor markers in dermatomyositis\/polymyositis patients in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Data were collected retrospectively from the database of Taichung Veterans General Hospital in Taiwan from 1998 to 2014. Patients who fulfilled Bohan and Peter criteria of dermatomyositis\/polymyositis were recruited. Serum level of tumor markers including carcinoembryonic antigen, alpha-fetoprotein, carbohydrate antigen 125, carbohydrate antigen 19-9 and carbohydrate antigen 15-3 were measured. The occurrence of malignancies and interstitial lung disease was identified. The association of tumor markers with malignancies and interstitial lung disease was examined using Chi-square test or Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among the enrolled 151 patients, 98 (64.9%) dermatomyositis and 53 (35.1%) polymyositis, a total of 15 malignancies were detected: breast ductal carcinoma (n\u2009=\u20094), bladder transitional cell carcinoma (n\u2009=\u20092), lung adenocarcinoma (n\u2009=\u20092), cervical intraepithelial neoplasia 3 and papillary squamous cell carcinoma (n\u2009=\u20092), colorectal (colon and rectal adenocarcinoma) (n\u2009=\u20092), uterine adenocarcinoma (n\u2009=\u20091), nasopharyngeal carcinoma (n\u2009=\u20091) and hematological malignancy (myelodysplastic with excess blast cells) (n\u2009=\u20091). Among the patients with malignancies, 13 (86.7%) had dermatomyositis, 2 (13.3%) polymyositis and 3 (20%) interstitial lung disease. The mean duration from dermatomyositis\/polymyositis diagnosis to the occurrence of malignancies was 6.05\u2009\u00b1\u20095.69\u2009years. There was no significant association of raised tumor markers with the occurrence of malignancies (p\u2009&gt;\u20090.085), while a significant association was observed between the elevated levels of carbohydrate antigen 15-3 and the presence of interstitial lung disease (p\u2009=\u20090.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Tumor markers were not useful in malignancy screening or dermatomyositis\/polymyositis patients in this tertiary center. The evaluation of the occurrence of malignancy in dermatomyositis\/polymyositis patient should include a multidimensional approach. A raised level of carbohydrate antigen 15-3 may be a potential indicator of the presence of interstitial lung disease in dermatomyositis\/polymyositis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050312118781895","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T06:36:24Z","timestamp":1529303784000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["The clinical application of tumor markers in the screening of malignancies and interstitial lung disease of dermatomyositis\/polymyositis patients: A retrospective study"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-2154","authenticated-orcid":false,"given":"Chong Hong","family":"Lim","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, Hospital Sultanah Bahiyah, Alor Setar, Malaysia"},{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Tsai","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Nan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"},{"name":"School of Medicine, National Yang-Ming 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