{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T17:24:23Z","timestamp":1780853063255,"version":"3.54.1"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Single-tablet regimens are preferred prescription choices for HIV treatment, but there are limited outcomes data comparing single-tablet regimens to multiple-tablet regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively assessed treatment-na\u00efve patients at a single urban HIV clinic in the United States for viral load suppression at 6 and 12\u2009months after initiating either single-tablet or multiple-tablet regimens. Multivariate regression was performed to obtain relative risks and adjust for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 218 patients, 47% were on single-tablet regimens and 53% on multiple-tablet regimens; 77% of single-tablet regimen patients had undetectable viral load at 6\u2009months compared to 61% of multiple-tablet regimen patients (p\u2009=\u20090.012). At 12\u2009months, 82% on single-tablet regimens and 66% on multiple-tablet regimens (p\u2009=\u20090.019) had undetectable viral load. Relative risk of any detectable viral load was 1.6 (95% confidence interval: 1.1\u20132.5) for patients on multiple-tablet regimens compared to single-tablet regimens at 6\u2009months, and 2.2 (95% confidence interval: 1.2\u20134.0) at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Single-tablet regimens may provide better virologic control than multiple-tablet regimens in urban HIV-infected persons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050312118816919","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T02:05:51Z","timestamp":1543975551000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["HIV virologic response better with single-tablet once daily regimens compared to multiple-tablet daily regimens"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6363-2839","authenticated-orcid":false,"given":"Shashi N","family":"Kapadia","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Grant","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan B","family":"German","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baljinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L","family":"Davidow","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Rutgers School of Public Health, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Hodder","sequence":"additional","affiliation":[{"name":"West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"bibr1-2050312118816919","unstructured":"Panel on Antiretroviral Guidelines for Adults Adolescents. 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