{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:39Z","timestamp":1793900199528,"version":"4.8.0"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"YYYYYYY","award":["FGTRYUI@##%"],"award-info":[{"award-number":["FGTRYUI@##%"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pharmacotherapy is important in reducing morbidity and mortality related to cardiovascular diseases. However, these advantages are limited by drug therapy problems that can impact on a patient\u2019s quality of life, prolong hospital stays, and increase the overall burden of healthcare expenditures. Therefore, this study was aimed to assess drug therapy problems among patients with cardiovascular diseases who were hospitalized and received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An institution-based cross-sectional study design was used to collect data from patients with cardiovascular diseases who were admitted to the medical ward and those who had received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital. The collected data were coded, entered, and analyzed using SPSS version 16. The associations of selected categorical variables were done using binary logistic and multivariate logistic regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of 216 study participants, females accounted for 123 (57%), whereas 93 (43%) of them were males. Among cardiovascular diseases identified in the medical ward and ambulatory clinics of Hiwot Fana Specialized University Hospital, congestive heart failure 96 (44.4%) and hypertension 93 (43.1%) were the two most commonly diagnosed disorders. Of the total participants involved in the study, 131 (60.65%) had drug therapy problems. Among the seven classes of drug therapy problems assessed, the most commonly observed was the need for additional drug therapy 76 (58%); followed by cases related to unnecessary drug therapy and noncompliance both of which were estimated to be 16 (12.2%). In addition, of independent variables, only the use of more than three drugs was significantly associated in both binary logistic (crude odds ratio\u2009=\u20090.41, 95% confidence interval\u2009=\u20090.234\u20130.719, p\u2009=\u20090.002) and multivariate logistic regressions (adjusted odds ratio\u2009=\u20094.86, 95% confidence interval\u2009=\u20091.625\u201314.536, p\u2009=\u20090.005) as compared with those patients who were using less than three drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings of the study indicated that more than half of the study participants experienced drug therapy problems, for which 58% required additional drug therapy. The risk of drug therapy problem is found to increase with the use of more than three drugs. Since these problems are adversely affecting the treatment outcome of patients, this is an area which requires special attention and the cooperation of healthcare professionals to tackle it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050312119860401","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T06:25:18Z","timestamp":1563517518000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Drug therapy problems among patients with cardiovascular disease admitted to the medical ward and had a follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital: The case of a tertiary hospital in eastern Ethiopia"],"prefix":"10.1177","volume":"7","author":[{"given":"Tamene","family":"Gelchu","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-8641","authenticated-orcid":false,"given":"Jemal","family":"Abdela","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"bibr1-2050312119860401","first-page":"42","volume":"3","author":"Abraham RR.","year":"2014","journal-title":"IJBMSP"},{"key":"bibr2-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(93)90096-M"},{"key":"bibr3-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-017-0145-1"},{"key":"bibr4-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-1007"},{"key":"bibr5-2050312119860401","first-page":"E84","volume":"9","author":"Misganaw A","year":"2012","journal-title":"Prev Chronic Dis"},{"key":"bibr6-2050312119860401","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v16i3.27"},{"key":"bibr7-2050312119860401","first-page":"S016","volume":"8","author":"Srikanth A.","year":"2017","journal-title":"J Basic Clin Pharm"},{"key":"bibr8-2050312119860401","doi-asserted-by":"publisher","DOI":"10.4103\/2279-042X.132702"},{"key":"bibr9-2050312119860401","volume-title":"Pharmaceutical care practice: the patient-centered approach to medication management","author":"Cipolle RJ","year":"2012"},{"key":"bibr10-2050312119860401","first-page":"258","volume":"6","author":"Kumar SBP","year":"2013","journal-title":"Asian J Pharmaceut Clin Res"},{"key":"bibr11-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014568008"},{"key":"bibr12-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-011-9497-y"},{"key":"bibr13-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002401114"},{"key":"bibr14-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024896328720"},{"issue":"17","key":"bibr15-2050312119860401","first-page":"1890","volume":"168","author":"Leendertse AJ","year":"2008","journal-title":"Arch Intern Med"},{"key":"bibr16-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200003000-00003"},{"key":"bibr17-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102073240604"},{"key":"bibr18-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.11.915.33630"},{"key":"bibr19-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199456"},{"key":"bibr20-2050312119860401","first-page":"2828","volume":"4","author":"Tegegne GT","year":"2014","journal-title":"IAJPR"},{"key":"bibr21-2050312119860401","volume-title":"Pharmaceutical care practice","author":"Strand LM","year":"2012"},{"key":"bibr22-2050312119860401","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00526"},{"key":"bibr23-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8807"},{"key":"bibr24-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-15961-4"},{"key":"bibr25-2050312119860401","volume-title":"Pharmacotherapy: a pathophysiologic approach","author":"DiPiro JT","year":"2014"},{"key":"bibr26-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.05.013"},{"key":"bibr27-2050312119860401","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"bibr28-2050312119860401","first-page":"5","volume":"1","author":"Schatz S","year":"2015","journal-title":"Pharm Prac"},{"key":"bibr29-2050312119860401","unstructured":"World Health Organization. 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