{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:16:24Z","timestamp":1792019784449,"version":"4.4.0"},"reference-count":195,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Nonalcoholic fatty liver disease is increasingly recognized as a major global health problem. Intertwined with diabetes, metabolic syndrome, and obesity, nonalcoholic fatty liver disease embraces a spectrum of liver conditions spanning from steatosis to inflammation, fibrosis, and liver failure. Compared with the general population, the prevalence of cardiovascular disease is higher among nonalcoholic fatty liver disease patients, in whom comprehensive cardiovascular risk assessment is highly desirable. Preclinical effects of nonalcoholic fatty liver disease on the heart include both metabolic and structural changes eventually preceding overt myocardial dysfunction. Particularly, nonalcoholic fatty liver disease is associated with enhanced atherosclerosis, heart muscle disease, valvular heart disease, and arrhythmias, with endothelial dysfunction, inflammation, metabolic dysregulation, and oxidative stress playing in the background. In this topical review, we aimed to summarize current evidence on the epidemiology of nonalcoholic fatty liver disease, discuss the pathophysiological links between nonalcoholic fatty liver disease and cardiovascular disease, illustrate nonalcoholic fatty liver disease\u2013related cardiovascular phenotypes, and finally provide a glimpse on the relationship between nonalcoholic fatty liver disease and cardiac steatosis, mitochondrial (dys)function, and cardiovascular autonomic dysfunction.<\/jats:p>","DOI":"10.1177\/2050312120933804","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T05:08:14Z","timestamp":1592629694000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Nonalcoholic fatty liver disease and cardiovascular disease phenotypes"],"prefix":"10.1177","volume":"8","author":[{"given":"Giandomenico","family":"Bisaccia","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, \u201cG. d\u2019Annunzio\u201d University of Chieti and Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-6623","authenticated-orcid":false,"given":"Fabrizio","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, \u201cG. d\u2019Annunzio\u201d University of Chieti and Pescara, Chieti, Italy"},{"name":"Department of Clinical Sciences, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Mantini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, \u201cG. d\u2019Annunzio\u201d University of Chieti and Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tana","sequence":"additional","affiliation":[{"name":"Internal Medicine and Critical Subacute Care Unit, Medicine Geriatric-Rehabilitation Department, and Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Romani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, \u201cG. d\u2019Annunzio\u201d University of Chieti and Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Department of Internistic Ultrasound, \u201cG. d\u2019Annunzio\u201d University of Chieti and Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Gallina","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, \u201cG. d\u2019Annunzio\u201d University of Chieti and Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,20]]},"reference":[{"key":"bibr1-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.050"},{"key":"bibr2-2050312120933804","volume-title":"Harrison\u2019s gastroenterology and hepatology","author":"Kasper DL.","year":"2017","edition":"3"},{"key":"bibr3-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"bibr4-2050312120933804","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i6.846"},{"key":"bibr5-2050312120933804","first-page":"360","volume":"107","author":"Bugianesi E","year":"2016","journal-title":"Recenti Prog Med"},{"key":"bibr6-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1419"},{"key":"bibr7-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.171"},{"key":"bibr8-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"bibr9-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002484"},{"key":"bibr10-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20466"},{"key":"bibr11-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.05.001"},{"key":"bibr12-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1562947"},{"key":"bibr13-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.091708.162036"},{"key":"bibr14-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/ng.257"},{"key":"bibr15-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P900013-JLR200"},{"key":"bibr16-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.02.030"},{"key":"bibr17-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.020"},{"key":"bibr18-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1183"},{"key":"bibr19-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5309"},{"key":"bibr20-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.11.014"},{"key":"bibr21-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-0992-9"},{"key":"bibr22-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28142"},{"key":"bibr23-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy124"},{"key":"bibr24-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1700428"},{"key":"bibr25-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27490"},{"key":"bibr26-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.032"},{"key":"bibr27-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23453-9"},{"key":"bibr28-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000193"},{"key":"bibr29-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/ng.784"},{"key":"bibr30-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309456"},{"key":"bibr31-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2893"},{"key":"bibr32-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311526"},{"key":"bibr33-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12038"},{"key":"bibr34-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2013.12.005"},{"key":"bibr35-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.06.010"},{"key":"bibr36-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139310"},{"key":"bibr37-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2446-4"},{"key":"bibr38-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2248"},{"key":"bibr39-2050312120933804","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00023"},{"key":"bibr40-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1177\/2050312117745223"},{"key":"bibr41-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0283-5"},{"key":"bibr42-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195147"},{"key":"bibr43-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"bibr44-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.027"},{"key":"bibr45-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.024"},{"key":"bibr46-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110114"},{"key":"bibr47-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.014"},{"key":"bibr48-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21327"},{"key":"bibr49-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.11.005"},{"key":"bibr50-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6891"},{"key":"bibr51-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26156"},{"key":"bibr52-2050312120933804","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1590"},{"key":"bibr53-2050312120933804","doi-asserted-by":"publisher","DOI":"10.2337\/cd18-0026"},{"key":"bibr54-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21827"},{"key":"bibr55-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13264"},{"key":"bibr56-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13299"},{"key":"bibr57-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091978"},{"issue":"2","key":"bibr58-2050312120933804","first-page":"64","volume":"36","author":"Glass LM","year":"2019","journal-title":"Fed Pract"},{"key":"bibr59-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.006."},{"issue":"8","key":"bibr60-2050312120933804","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2337\/db18-1048","volume":"68","author":"De Silva NMG","year":"2019","journal-title":"Diabetes"},{"key":"bibr61-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182779d49"},{"key":"bibr62-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1264-3"},{"key":"bibr63-2050312120933804","first-page":"216","volume":"5","author":"Kumar R","year":"2017","journal-title":"J Clin Transl Hepatol"},{"key":"bibr64-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.04.045"},{"key":"bibr65-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0556-1"},{"key":"bibr66-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33573"},{"key":"bibr67-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-13"},{"key":"bibr68-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24097"},{"key":"bibr69-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2649"},{"key":"bibr70-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2016.10.004"},{"key":"bibr71-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"bibr72-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4040-6"},{"key":"bibr73-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.005"},{"key":"bibr74-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.103"},{"key":"bibr75-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20781"},{"key":"bibr76-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.07.027"},{"key":"bibr77-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.001"},{"key":"bibr78-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26219"},{"key":"bibr79-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.053"},{"key":"bibr80-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23719"},{"key":"bibr81-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1075-y"},{"key":"bibr82-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1177\/204748730000700504"},{"key":"bibr83-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.07.003"},{"key":"bibr84-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303034"},{"key":"bibr85-2050312120933804","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2016.31.1.1"},{"key":"bibr86-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.56"},{"key":"bibr87-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0864"},{"key":"bibr88-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120542"},{"key":"bibr89-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.814418"},{"key":"bibr90-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.054"},{"key":"bibr91-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.018"},{"key":"bibr92-2050312120933804","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2013.37.1.63"},{"key":"bibr93-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01817.x"},{"key":"bibr94-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03891.x"},{"key":"bibr95-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-37"},{"key":"bibr96-2050312120933804","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151121202"},{"key":"bibr97-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31488-7"},{"key":"bibr98-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30159.x"},{"key":"bibr99-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000212608.59090.08"},{"key":"bibr100-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"bibr101-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.06.009"},{"key":"bibr102-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136822"},{"key":"bibr103-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.05.070"},{"key":"bibr104-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040174"},{"key":"bibr105-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01774.x"},{"key":"bibr106-2050312120933804","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9880.1000344"},{"key":"bibr107-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.044"},{"key":"bibr108-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2014.43"},{"key":"bibr109-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2060-x"},{"key":"bibr110-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02639.x"},{"key":"bibr111-2050312120933804","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501175"},{"key":"bibr112-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13183"},{"key":"bibr113-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/srep08096"},{"key":"bibr114-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.023"},{"key":"bibr115-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12145"},{"key":"bibr116-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00604.2005"},{"key":"bibr117-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1159\/000282088"},{"key":"bibr118-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"bibr119-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.049"},{"key":"bibr120-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1365"},{"key":"bibr121-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/s41424-018-0034-3"},{"key":"bibr122-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29359"},{"key":"bibr123-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304163"},{"key":"bibr124-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28890"},{"key":"bibr125-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00212-0"},{"key":"bibr126-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.09.023"},{"key":"bibr127-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.06.010"},{"key":"bibr128-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162473"},{"key":"bibr129-2050312120933804","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S168345"},{"key":"bibr130-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.01.008"},{"key":"bibr131-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1089\/met.2016.0132"},{"key":"bibr132-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01454-6"},{"key":"bibr133-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.112.974956"},{"key":"bibr134-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10030"},{"key":"bibr135-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.58"},{"key":"bibr136-2050312120933804","first-page":"1294","volume":"38","author":"Wong CX","year":"2017","journal-title":"Eur Heart J"},{"key":"bibr137-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0165-y"},{"key":"bibr138-2050312120933804","first-page":"2","volume":"9","author":"Anumonwo JMB","year":"2018","journal-title":"potential cellular and molecular mechanisms. Front Physiol"},{"key":"bibr139-2050312120933804","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i30.3361"},{"key":"bibr140-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"bibr141-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04556.x"},{"key":"bibr142-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300604"},{"key":"bibr143-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"bibr144-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29721"},{"key":"bibr145-2050312120933804","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2018.00021"},{"key":"bibr146-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29393"},{"key":"bibr147-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"bibr148-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13857"},{"key":"bibr149-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12685"},{"key":"bibr150-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"bibr151-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02753.x"},{"key":"bibr152-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1428"},{"key":"bibr153-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000286"},{"key":"bibr154-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00081-2"},{"key":"bibr155-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.044842"},{"issue":"4","key":"bibr156-2050312120933804","first-page":"393","volume":"40","author":"Palmieri L","year":"2004","journal-title":"Ann Ist Super Sanita"},{"key":"bibr157-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2015.965143"},{"key":"bibr158-2050312120933804","doi-asserted-by":"publisher","DOI":"10.7869\/tg.2012.101"},{"key":"bibr159-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(17)31626-4"},{"key":"bibr160-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15192"},{"key":"bibr161-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23314"},{"key":"bibr162-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"bibr163-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25855"},{"key":"bibr164-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.12.033"},{"key":"bibr165-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1038\/srep33386"},{"key":"bibr166-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28253"},{"key":"bibr167-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12665"},{"key":"bibr168-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912063"},{"key":"bibr169-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.06.012"},{"key":"bibr170-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.09.002"},{"key":"bibr171-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(16)31616-3"},{"key":"bibr172-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140933"},{"key":"bibr173-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.107"},{"key":"bibr174-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(18)31922-6"},{"key":"bibr175-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27869"},{"key":"bibr176-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130298"},{"key":"bibr177-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.04.003"},{"key":"bibr178-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088371"},{"key":"bibr179-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-018-0895-2"},{"key":"bibr180-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.162"},{"key":"bibr181-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-009-0031-4"},{"key":"bibr182-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1159\/000282089"},{"key":"bibr183-2050312120933804","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.890741"},{"key":"bibr184-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411804"},{"key":"bibr185-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005505"},{"key":"bibr186-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061803"},{"key":"bibr187-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5160754"},{"key":"bibr188-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.035"},{"key":"bibr189-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.09.021"},{"key":"bibr190-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057183"},{"key":"bibr191-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1177\/0161734615595015"},{"key":"bibr192-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1888"},{"key":"bibr193-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"bibr194-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.01.005"},{"key":"bibr195-2050312120933804","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001820"}],"container-title":["SAGE Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050312120933804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050312120933804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050312120933804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:17:35Z","timestamp":1777594655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050312120933804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":195,"alternative-id":["10.1177\/2050312120933804"],"URL":"https:\/\/doi.org\/10.1177\/2050312120933804","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050312120933804"}}